This article investigates the unsteady mixed convention two-dimensional flow of magnetohydrodynamic Casson hybrid nanofluids (alumina oxide and titanium oxide nanoparticles with base fluid water) flow through porous media over a linearly stretched sheet. We analyzed the heat and mass transfer in mixed convection, thermal radiation, variable thermal conductivity, variable mass diffusivity, and chemical reaction in the presence of thermophoresis and Brownian motion. A system of partial differential equations is reduced to a solvable system of ordinary differential equations by applying a suitable similarity transformation. We used the Runga–Kutta method along with the shooting procedure to solve the flow, heat, and mass transfer equations along with boundary conditions. The results obtained from MATLAB codes are compared with previously published results of the same type in a limiting case. The results of the velocity, temperature, and concentration profile of the hybrid nanofluid for varying different flow parameters are obtained in the form of graphs, while the rate of shear stress, rate of heat, and mass transfer are expressed in tables. We noticed that velocity and temperature diminish as an unsteady parameter increases; however, the reverse trend was observed in the nanoparticle concentration profile. With an increase in the thermal radiation parameter, the resultant velocity and temperature profile improves, while the concentration of nanoparticle profiles decreases. The velocity and temperature increase with higher Brownian motion, while the velocity increases and temperature decreases with higher thermophoresis.