Influence of Radiation Dose and Reconstruction Kernel on Fat Fraction Analysis in Dual-energy CT: A Phantom Study

Chatzaraki, Vasiliki; Born, Corinna; Kubik‐Huch, Rahel A.; Froehlich, Johannes M.; Thali, Michael J.; Niemann, Tilo

doi:10.21873/invivo.12609

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Reconstruction kernels are algorithms used to modify the frequency content of the image data prior to back projection, allowing image sharpening (higher spatial resolution, but increased image noise) or softening (low noise, but relatively low spatial resolution), depending on the specific objective of each image study. For instance, softer kernels are usually recommended for accurate attenuation measurements and sharper ones reduce the attenuation of atherosclerotic plaques [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Pros and Cons of Dual-Energy CT Systems: “One Does Not Fit All”

2023

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Dual-energy computed tomography (DECT) uses different energy spectrum X-ray beams for differentiating materials with similar attenuation at a certain energy. Compared with single-energy CT, it provides images with better diagnostic performance and a potential reduction of contrast agent and radiation doses. There are different commercially available DECT technologies, with machines that may display two X-ray sources and two detectors, a single source capable of fast switching between two energy levels, a specialized detector capable of acquiring high- and low-energy data sets, and a filter splitting the beam into high- and low-energy beams at the output. Sequential acquisition at different tube voltages is an alternative approach. This narrative review describes the DECT technique using a Q&A format and visual representations. Physical concepts, parameters influencing image quality, postprocessing methods, applicability in daily routine workflow, and radiation considerations are discussed. Differences between scanners are described, regarding design, image quality variabilities, and their advantages and limitations. Additionally, current clinical applications are listed, and future perspectives for spectral CT imaging are addressed. Acknowledging the strengths and weaknesses of different DECT scanners is important, as these could be adapted to each patient, clinical scenario, and financial capability. This technology is undoubtedly valuable and will certainly keep improving.

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Section: Resultsmentioning

confidence: 99%

Pros and Cons of Dual-Energy CT Systems: “One Does Not Fit All”

2023

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“…In the literature, several studies have been performed concerning image quality in complex CT acquisitions (21)(22)(23), but without focusing on obese patients. Our study has several limitations.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Image Quality in Chest CT With Precision Matrix and Increased Framing Rate Using Single Source CT: A Phantom Study

Mavridis

El-Gedaily

Kubik‐Huch

et al. 2023

In Vivo

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Background/Aim: The aim was to evaluate the effect of a combined precision matrix and high sampling rate on the delineation of anatomical structures and objective image quality in single source CT in a qualitative approach. Materials and Methods: An anthropomorphic thoracic phantom was used to evaluate the objective image quality parameters, including image noise, noise power spectrum, image stepness and Q for different CT scanners including high/ standard matrix and framing frequency setups. Scan parameters were standardized over all scanners. Additional subjective quality assessment was also performed. Results: A linear mixed effects model was used to determine the effect of sampling rate and image matrix on objective image quality parameters. Noise power spectrum and image noise were significantly influenced by both framing frequency and image matrix. There were significant differences between high and standard frequency/ matrix acquisitions. Conclusion: Higher framing frequency and image matrix allows for improved image noise texture and objective image quality in CT.

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In vitro blood sample assessment: investigating correlation of laboratory hemoglobin and spectral properties of dual-energy CT measurements (ρ/Z)

Schulz,

Euler,

Schmid

et al. 2024

Eur Radiol

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Objectives Our study comprised a single-center retrospective in vitro correlation between spectral properties, namely ρ/Z values, derived from scanning blood samples using dual-energy computed tomography (DECT) with the corresponding laboratory hemoglobin/hematocrit (Hb/Hct) levels and assessed the potential in anemia-detection. Methods DECT of 813 patient blood samples from 465 women and 348 men was conducted using a standardized scan protocol. Electron density relative to water (ρ or rho), effective atomic number (Zeff), and CT attenuation (Hounsfield unit) were measured. Results Positive correlation with the Hb/Hct was shown for ρ (r-values 0.37–0.49) and attenuation (r-values 0.59–0.83) while no correlation was observed for Zeff (r-values −0.04 to 0.08). Significant differences in attenuation and ρ values were detected for blood samples with and without anemia in both genders (p value < 0.001) with area under the curve ranging from 0.7 to 0.95. Depending on the respective CT parameters, various cutoff values for CT-based anemia detection could be determined. Conclusion In summary, our study investigated the correlation between DECT measurements and Hb/Hct levels, emphasizing novel aspects of ρ and Zeff values. Assuming that quantitative changes in the number of hemoglobin proteins might alter the mean Zeff values, the results of our study show that there is no measurable correlation on the atomic level using DECT. We established a positive in vitro correlation between Hb/Hct values and ρ. Nevertheless, attenuation emerged as the most strongly correlated parameter with identifiable cutoff values, highlighting its preference for CT-based anemia detection. Clinical relevance statement By scanning multiple blood samples with dual-energy CT scans and comparing the measurements with standard laboratory blood tests, we were able to underscore the potential of CT-based anemia detection and its advantages in clinical practice. Key Points Prior in vivo studies have found a correlation between aortic blood pool and measured hemoglobin and hematocrit. Hemoglobin and hematocrit correlated with electron density relative to water and attenuation but not Zeff. Dual-energy CT has the potential for additional clinical benefits, such as CT-based anemia detection. Graphical Abstract

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Influence of Radiation Dose and Reconstruction Kernel on Fat Fraction Analysis in Dual-energy CT: A Phantom Study

Cited by 4 publications

References 14 publications

Pros and Cons of Dual-Energy CT Systems: “One Does Not Fit All”

Pros and Cons of Dual-Energy CT Systems: “One Does Not Fit All”

Assessment of Image Quality in Chest CT With Precision Matrix and Increased Framing Rate Using Single Source CT: A Phantom Study

In vitro blood sample assessment: investigating correlation of laboratory hemoglobin and spectral properties of dual-energy CT measurements (ρ/Z)

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