Influence of  -radiation sterilisation in properties of new chitosan/soybean protein isolate membranes for guided bone regeneration

Abstract

Novel chitosan (cts) and soybean protein isolate (SI) blended membranes were prepared. These membranes were produced by solvent casting. Besides combining the advantages of both materials, cts/SI membranes exhibit a biphasic structure that will eventually originate in situ porous formation, through a two-step degradation mechanism. In this particular work the effect of beta-radiation over the properties of these membranes was evaluated. beta-radiation sterilisation was performed at three different doses (25, 50 and 100 kGy) and eventual surface chemical changes were evaluated by Fourier transformed infrared--with attenuated total reflection and contact angle measurements. Moreover, eventual bulk properties changes due to beta-radiation were assessed by means of mechanical tensile tests and water uptake measurements. In general, no substantial changes were detected on the studied properties, with the exception of the surface energy that was found to be slightly increased for higher applied doses.

Effects of the Dichloromethane Fraction of Dipsaci Radix on the Osteoblastic Differentiation of Human Alveolar Bone Marrow-Derived Mesenchymal Stem Cells

“…22,23) Soybean extracts are applied as bone fillers and regenerative materials. 24,25) Safflower seeds are commonly used as a natural remedy to treat bone fractures in traditional Korean medicine, and have recently been used in regenerative applications. 26,27) Other data on safflower seeds include application to the treatment of periodontal 1-wall intrabony defects, 28) and in the prevention of bone resorption caused by estrogen deficiency.…”

Bio-scaffolds produced from irradiated squid pen and crab chitosan with hydroxyapatite/β-tricalcium phosphate for bone-tissue engineering

“…[26] (PVA), N O, car-boxymethyl chitosan/(PEG) (e-beam) radiation was used to physically cross-link the polymers at 30 kGy and 50 kGy.…”

“…Irradiated crab squid pen chitosan had a molecular weight of 215 kDa, and 384 kDa measured using gel permeation chromatography (GPC) as described by [28]. The samples had viscosity of 0.05 (RC) and 0.23 (RS) Pa.s with a degree of deacetylation (DDA) of 81.39% for RC and 85.66% for RS sample based on the elemental analysis method previously described by Youn et al [26]. The samples' ash content were below 1% (0.58 for RC and 0.65% for RS).…”

Ecomaterials Based on Food Proteins and Polysaccharides

“…β-Radiation is suitable to sterilize the membranes without significant influences to mechanical properties except for a slight increase in surface energy. 191 A crosslinked porous structure based on soy protein/chitosan blends can be developed by means of combining a sol-gel process with the freeze-drying technique. 126 Addition of tetraethyl orthosilicate to the blend provides specific interfacial interactions at the interface between the two polymers, allowing tailoring the size and distribution as well as the degradation rate of the hybrids.…”