Radon is a topic with little research in Perú, it is very relevant to do a study on it and show how radon affects the population. The objective of the research was to analyze Radon 222, as a silent enemy of health through a systematic review. Methodology: the systematic review article has a qualitative approach, the Prism methodology was used, and the analysis of the documents was from the search in specialized databases of Scopus, Web Of Science, Scielo and on the Internet, similar search strategies were applied through the Boolean operators AND and OR, two keywords were taken from a health thesaurus. The results show that a derivative of uranium is radon Rn 222 found in high concentrations in buildings, water, soil and especially in granite rocks. Radiation exposure and its adverse effects on respiratory health pose a significant risk to public health. Public policies in Perú are weak in relation to the issue. It is concluded that radon Rn 222 is a gas that silently affects Society and is a cause of cancer in the lung of humanity. Peru's nuclear power governing body has little up-to-date research on radon.