The need of society toward end-of-life care is increasing, especially for the client being cared in the ICU setting, where nursing role is critical in this context. Some studies have indicated that nurses often feel distressed in caring for those clients. The nursing knowledge related to caring for the client in the end-of-life phase is, therefore, important for improving the nurse's insights. This study employed qualitative phenomenological approach, focused on exploring the experience of nurses in providing end-of-life care to the clients and their families in ICU setting. Seven participants have participated in this study. Data collection was undertaken through in-depth interview and analyzed using Colizzi approach. The results of the study have described this phenomenon on four themes: the life and death is God's secret; the dilemma between doing the best for the client and terminating life support; Supporting the clients and families; Re lecting on the experience. The results of this study have a potential to expand the nursing knowledge related to end-of-life care as well as have the potential of improving the quality of care services provided to the clients in end-of-life phase.