Influence of Renin Levels on the Treatment of Essential Hypertension With Thiazide Diuretics

Wyndham, Roger

doi:10.1001/archinte.1987.00370060017003

Cited by 5 publications

(1 citation statement)

References 32 publications

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“…Several observational studies confirmed the predictive value of renin levels to the response to β-blockers, thiazide diuretics, and mineralocorticoid receptorblockers (for a review of these studies, see [66]). Other reports, Review however, failed to observe an association between pre-treatment renin levels and response to β-blockers and/or diuretics [67][68][69][70]. Later, a number of studies investigated the association between pre-treatment renin profiling and response to anti-hypertensive drug classes other than β-blockers and diuretics.…”

Section: Clinical Confirmation and Current Controversies Of Laragh's mentioning

confidence: 99%

Renin and Aldosterone Measurements in the Management of Arterial Hypertension

et al. 2015

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▼Renin-angiotensin-aldosterone system (RAAS) is recognized as the main regulatory system of hemodynamics in man, and its derangements have a key role in the development and maintenance of arterial hypertension. Classification of the hypertensive states according to different patterns of renin and aldosterone levels ("RAAS profiling") allows the diagnosis of specific forms of secondary hypertension and may identify distinct hemodynamic subsets in essential hypertension. In this review, we summarize the application of RAAS profiling for the diagnostic assessment of hypertensive patients and discuss how the pathophysiological framework provided by RAAS profiling may guide therapeutic decision-making, especially in the context of uncontrolled hypertension not responding to multi-therapy.

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