Influence of residual oxygen-15-labeled carbon monoxide radioactivity on cerebral blood flow and oxygen extraction fraction in a dual-tracer autoradiographic method

Iwanishi, Katsuhiro; Watabe, Hiroshi; Hayashi, Takuya; Miyake, Yoichi; Minato, Kotaro; Iida, Hidehiro

doi:10.1007/s12149-009-0243-7

Cited by 6 publications

(6 citation statements)

References 16 publications

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“…eNOS mediates the basal release of NO to regulate the cerebral blood flow in various mammals. This role of NO has been confirmed by various recent researches using NOS inhibitors [ 38 – 40 ].…”

Section: Introductionsupporting

confidence: 56%

Hydrogen sulfide, nitric oxide, and neurodegenerative disorders

Panthi

Manandhar

Gautam

2018

Transl Neurodegener

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Hydrogen Sulfide (H2S) and Nitric Oxide (NO) have become recognized as important gaseous signaling molecules with enormous pharmacological effects, therapeutic value, and central physiological roles. NO is one of the most important regulators of the pathophysiological condition in central nervous system (CNS). It is critical in the various functioning of the brain; however, beyond certain concentration/level, it is toxic. H2S was regarded as toxic gas with the smell like rotten egg. But, it is now regarded as emerging neuroprotectant and neuromodulator. Recently, the use of donors and inhibitors of these signaling molecules have helped us to identify their accurate and precise biological effects. The most abundant neurotransmitter of CNS (glutamate) is the initiator of the reaction that forms NO, and H2S is highly expressed in brain. These molecules are shedding light on the pathogenesis of various neurological disorders. This review is mainly focused on the importance of H2S and NO for normal functioning of CNS.

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Section: Introductionsupporting

confidence: 56%

Hydrogen sulfide, nitric oxide, and neurodegenerative disorders

Panthi

Manandhar

Gautam

2018

Transl Neurodegener

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“…The regulation of the smooth muscle tone in vessels as well as blood flow is regulated by NO, which is produced by the adrenergic neurons and endothelial cells (Table 1). NOS inhibitors, NO scavengers, and sGC inhibitors reduce cerebral blood flow and promote vasoconstriction (Toda (Iwanishi et al, 2009). Basal release of NO induces increased cerebral blood flow in various mammals and is mediated by eNOS.…”

Section: Cerebral Blood Flowmentioning

confidence: 99%

L-Arginine and Nitric Oxide in CNS Function and Neurodegenerative Diseases

Virarkar

Alappat

Bradford

et al. 2013

Critical Reviews in Food Science and Nutrition

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One of the main functions of L-arginine (ARG) is the synthesis of nitric oxide (NO). NO is an important regulator of physiological processes in the central nervous system (CNS). NO promotes optimal cerebral blood flow, consolidates memory processes, facilitates long-term potentiation, maintains sleep-wake cycles, and assists in normal olfaction. However, at pathological levels, NO adversely affects brain function producing nitroxidative stress and promoting development of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and other disorders of the CNS. This review summarizes current knowledge of the role of NO in the CNS and the role of diet in regulating the levels of NO.

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“…Conventional DARG measurement in clinical study uses 10 min of transmission scan, while 9 min of emission scan of dual tracers of 15 O 2 and H 2 15 O, in addition to 4 min of C 15 O scan [22]. If one can shorten the transmission scan to 3 min, total scan duration is 16 min (30% reduction).…”

Section: Discussionmentioning

confidence: 99%