For four types of railway rails, corresponding rolling tests have been executed by using the JD-1 wheel/rail simulation device based on the Hertz simulation method, which can ensure the reciprocal contact condition between simulation rail and wheel under experimental conditions approximate to practical contact conditions. The results indicate that, for the rail material which has a higher hardness, the wear volume was less and the plastic deformation layer was thinner after the rolling test, but the crack propagation was more significant and the fatigue damage was severer, showing that its wear resistance was better. The analysis shows that the fatigue resistance of U71Mn rail was better, and considering fatigue is the main failure type for high-speed rail, so it is more suited to the high-speed railway.