Influence of Resistance Training on Neuromuscular Function and Physical Capacity in ALS Patients

Jensen, Line; Djurtoft, J B; Bech, Rune Dueholm; Nielsen, Jakob Lindberg; Jørgensen, Louise Helskov; Aagaard, Per; Hvid, Lars G.

doi:10.1155/2017/1436519

Cited by 18 publications

(16 citation statements)

References 25 publications

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“…[3,8] The neuromuscular function including several parts: muscle strength; muscle power; muscle endurance; voluntary muscle activation; and proprioception. [9] The lumbar neuromuscular function may not only be responsible in improving the quality of patient's daily life and decreasing the pain, but also in maintaining the stability of the lumbar vertebra. [10] Hence, the correlations of the lumbar neuromuscular function with pain and lumbar disability need to be explored.…”

Section: Introductionmentioning

confidence: 99%

Correlations between lumbar neuromuscular function and pain, lumbar disability in patients with nonspecific low back pain

Wang²,

Chen³

et al. 2017

Medicine

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This study aims to examine the correlations between lumbar neuromuscular function and pain, lumbar disability in patients with nonspecific low back pain (NSLBP).Ninety patients, with ages 18 to 37 years old, with NSLBP were recruited in this study. The lumbar neuromuscular function was tested by the CON-TREX multijoint isokinetic test and training machine. This study uses the visual analog scale (VAS) and Roland-Morris Disability Questionnaire (RMDQ) to evaluate the pain and the dysfunction index of patients who have low back pain, respectively.Pearson correlation coefficient is used to evaluate the correlation between lumbar neuromuscular function and the VAS and RMDQ scores. VAS and RMDQ scores have correlations with the proprioception in the flexion of the lumbar vertebra flexion; the peak torque of both flexion and extension muscle groups; and average power and endurance at different angular velocities. The decrease of lumbar muscle strength, endurance, and lumbar proprioception of the lumbar vertebra leads to an increase in pain intensity and lumbar disability.This study suggests that patients with chronic low back pain require targeted training in muscle strength, endurance, and lumbar proprioception, providing a theoretical basis for prevention and treatment of chronic NSLBP patients.

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Section: Introductionmentioning

confidence: 99%

Correlations between lumbar neuromuscular function and pain, lumbar disability in patients with nonspecific low back pain

Wang²,

Chen³

et al. 2017

Medicine

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“…Previous studies have demonstrated that resistance or concurrent exercises (such as resistance and endurance exercises) are effective for improving muscle strength in patients with mild ALS 6 , 7 , 8 , 9 ) . However, other studies failed to show any improvement 10 , 11 ) . In general, there is conflicting evidence about the value of exercise in patients with ALS and who the best candidates might be.…”

Section: Introductionmentioning

confidence: 93%

Lower limb muscle strengthening exercises in patients with early-stage amyotrophic lateral sclerosis: a case series study

et al. 2020

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[Purpose] We investigated whether patients with early-stage amyotrophic lateral sclerosis can improve their voluntary strength with a physical therapy program. [Participants and Methods] This retrospective case series study at a single university hospital included 13 patients with amyotrophic lateral sclerosis (amyotrophic lateral sclerosis functional rating scale-revised ≥35, modified functional ambulation categories score ≥4). Physical therapy was performed for 3 weeks. We investigated knee extension muscle strength and modified functional ambulation categories scores at the start and end of the therapy and calculated the improvement rate of knee extension muscle strength. We performed a regression analysis of the relationship between knee extension muscle strength at the start of the study and the improvement rate. [Results] The knee extension muscle strength improved significantly; however, the effect size was small (0.13). The modified functional ambulation categories scores did not improve significantly. The knee extension muscle strength at the start of the therapy was negatively correlated with the improvement rate (logarithmic transformed linear regression: adjusted R 2 =0.27). [Conclusion] A short-duration exercise program improved lower limb muscle strength in patients with early-stage amyotrophic lateral sclerosis. Additionally, we found that patients with weaker lower limb muscle strength at the start of the therapy demonstrated greater improvement at the end of the therapy.

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“…In preclinical studies, data are conflicting as exercise has been suggested to be beneficial (44), null (45) or even harmful (46) in transgenic SOD1 G93A mice. Similarly, in humans, there are studies supporting the benefit of exercise training on the quality of life for ALS patients (47, 48), while other studies concluded that exercise had negative outcomes on neuromuscular function of ALS patients (49). Irrespective of these findings, physical activity is still considered a potential therapeutic approach for ALS improving body function, slowing disease progression and lessening caregiver burden (50).…”

Section: Introductionmentioning

confidence: 98%

The Role of Exercise as a Non-pharmacological Therapeutic Approach for Amyotrophic Lateral Sclerosis: Beneficial or Detrimental?

et al. 2019

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Amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, involves the rapid deterioration of motor neurons resulting in severe muscle atrophy and respiratory insufficiency. It is considered a “multisystemic” disease with many potential mechanisms responsible for its pathology. Currently, there is no cure for ALS. Exercise training is suggested as a potential approach to reduce ALS pathology, but its beneficial role remains controversial. This review provides an overview of the effects of exercise training in ALS-affected mice and patients. It will compare the intensity, duration, and type of exercise on the health of SOD1 G93A mice, a mouse model of familial ALS, and review clinical studies involving ALS patients undergoing both endurance and resistance training. In summary, mild-to-moderate swimming-based endurance training appears the most advantageous mode of exercise in SOD1 G93A mice, improving animal survival, and delaying the onset and progression of disease. Furthermore, clinical studies show that both endurance and resistance training have an advantageous impact on the quality of life of ALS patients without extending life expectancy. However, small sample sizes, non-representative control populations, heterogeneous disease stage of patients, and the presence of confounders often exist in the exercise studies conducted with ALS patients. This raises concerns about the interpretation of these findings and, therefore, these results should be considered with caution. While promising, more pre-clinical and clinical studies with improved experimental design and fewer limitations are still necessary to confirm the impact of exercise training on the health of ALS patients.

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Influence of Resistance Training on Neuromuscular Function and Physical Capacity in ALS Patients

Cited by 18 publications

References 25 publications

Correlations between lumbar neuromuscular function and pain, lumbar disability in patients with nonspecific low back pain

Correlations between lumbar neuromuscular function and pain, lumbar disability in patients with nonspecific low back pain

Lower limb muscle strengthening exercises in patients with early-stage amyotrophic lateral sclerosis: a case series study

The Role of Exercise as a Non-pharmacological Therapeutic Approach for Amyotrophic Lateral Sclerosis: Beneficial or Detrimental?

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