Influence of seasonal fluctuations, sex, and age on epoxide synthetase and epoxide hydrolase activities of the xenobiotic-metabolizing enzyme system

Суханов, В. В.; Sotnichenko, A. I.; Serdyuk, O. A.; Fedorova, T. Yu.; Saprin, A. N.; Piruzyan, L. A.

doi:10.1134/s0012496609060052

Cited by 1 publication

(1 citation statement)

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“…reported that rat lung microsomes hydrolyzed diepoxybutane with a much higher V max /K m efficiency (19.2) than the mouse (3.93) providing a likely contribution for the much lower susceptibility to the carcinogenicity of the parent compound butadiene of the rat lung compared with the mouse lung. Sukhanov et al (2009) reported on rats, which were kept in vivariums, marked seasonal changes in pulmonary mEH activities (for phenanthrene 9,10 oxide as substrate), with two peaks, a steep peak in March (3-to 4-fold difference compared with the preceding lowest values) and a smoother peak in July to August. In contrast to the liver, the mEH activity in the lung was higher in females than in males.…”

Section: Epoxide Hydrolase (Eh)mentioning

confidence: 98%

Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models

2019

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The xenobiotic metabolism in the lung, an organ of first entry of xenobiotics into the organism, is crucial for inhaled compounds entering this organ intentionally (e.g. drugs) and unintentionally (e.g. work place and environmental compounds). Additionally, local metabolism by enzymes preferentially or exclusively occurring in the lung is important for favorable or toxic effects of xenobiotics entering the organism also by routes other than by inhalation. The data collected in this review show that generally activities of cytochromes P450 are low in the lung of all investigated species and in vitro models. Other oxidoreductases may turn out to be more important, but are largely not investigated. Phase II enzymes are generally much higher with the exception of UGT glucuronosyltransferases which are generally very low. Insofar as data are available the xenobiotic metabolism in the lung of monkeys comes closed to that in the human lung; however, very few data are available for this comparison. Second best rate the mouse and rat lung, followed by the rabbit. Of the human in vitro model primary cells in culture, such as alveolar macrophages and alveolar type II cells as well as the A549 cell line appear quite acceptable. However, (1) this generalization represents a temporary oversimplification born from the lack of more comparable data; (2) the relative suitability of individual species/models is different for different enzymes; (3) when more data become available, the conclusions derived from these comparisons quite possibly may change.

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Section: Epoxide Hydrolase (Eh)mentioning

confidence: 98%