Due to the continuously increasing power density of electronic devices, the improvement of the temperature uniformity and the reduction of the irreversible energy losses became crucial in these studies on enhanced cooling capacity of the heat sinks. In this paper, a jet impingement microchannel heat sink with airfoil fins (AF‐JIMHS) is proposed. The AF‐JIMHS with reversed fins arrangement has very high comprehensive heat transfer performance. The increase of the internal tangent circle radius and chord length of fin can improve the temperature uniformity of the AF‐JIMHS bottom surface and reduce the irreversible energy losses, at the expense of reducing its comprehensive heat transfer performance. Although the increase of the tangent arc length of fin reduces the temperature uniformity and increases the irreversible energy losses of the AF‐JIMHS, it improves the comprehensive heat transfer performance in a specific parameter range. The increase of fin height improves temperature uniformity of the AF‐JIMHS, while reducing its irreversible energy losses and improving its comprehensive heat transfer performance. Compared with the AF‐JIMHS with uniform height fins, the one with decreasing height fins has higher comprehensive heat transfer performance and lower irreversible energy losses. Moreover, the AF‐JIMHS with increasing height fins has better temperature uniformity.