The study is a descriptive survey aimed to determine factors influencing Problem solving ability and its correlation to Communication Competency, Self-Directed Learning Ability, Selfleadership, and Problem Solving Ability of nursing college students. The data were collected from nursing students in one universities through structured questionnaires. Data were analyzed using SPSS/WIN 24.0, Descriptive statistics, t-test, ANOVA, Pearson's Correlation coefficients, Multiple regression, and Schéffe's test. Based on the result, Communication Competency by general characteristics revealed that there are significant differences in Personality, Major satisfaction and Application Motivation. Self-Directed Learning Ability had a significant differences in Gender, Personnality. Self-Leadership had significantly the differences in Gender, Grade, Personality, Major satisfaction and Application Motivation. And there are significant differences in Grade, Major satisfaction and Application Motivation in Problem Solving Ability. Problem Solving Ability had significant positive correlation with Communication Competency, Self-directed Learning Ability Selfleadership, and Problem Solving Ability of nursing students. The factors influencing on the Problem Solving Ability presented that Communication Competency and Self-leadership. The explanatory power of the model was 73.0%. As a result, it's necessary to prepare some strateges to improve program Communication Competency, Self-leadership and Problem Solving Ability improvement of nursing students.