Influence of sensitization on the discriminative stimulus effects of methylphenidate in mice

McGovern, Robin; Luderman, Lauryn N.; Knecht, Kelly; Griffin, William C.

doi:10.1097/fbp.0000000000000095

Cited by 3 publications

(2 citation statements)

References 68 publications

(109 reference statements)

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“…Additionally, to extend our earlier work looking at the effects of acute administration of these drugs on locomotion (Hilbert et al , 2013), we measured locomotor activity in an open field after the first oral gavage and then again after repeated oral gavage. Following from our earlier work (Griffin et al , 2013; Griffin et al , 2010; Hilbert et al , 2013; McGovern et al , 2014), our general hypothesis was that caffeine would increase the stimulatory effects of ethanol when administered acutely and that these effects would increase with repeated exposure.…”

Section: Introductionmentioning

confidence: 99%

Sensitization and Tolerance Following Repeated Exposure to Caffeine and Alcohol in Mice

May

Haun

Griffin

2015

Alcohol Clin Exp Res

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Introduction Energy drinks are popular mixers with alcohol. While energy drinks contain many ingredients, caffeine is an important pharmacologically active component and is generally present in larger amounts than in other caffeinated beverages. In these studies, we investigated the hypothesis that caffeine would influence the effects of alcohol (ethanol) on conditioned taste aversion, ataxia and locomotor activity after repeated exposure. Methods Four groups of mice were exposed by oral gavage twice daily to vehicle, ethanol (4 g/kg), caffeine (15 mg/kg), or the ethanol/caffeine combination. Conditioned taste aversion to saccharin and ataxia in the parallel rod task were evaluated after 8 or 16 gavages, respectively, using ethanol (1–3 g/kg) or ethanol/caffeine (3mg/kg + 2 g/kg) challenges. In addition, locomotor activity was evaluated initially and after repeated exposure to oral gavage of these drugs and doses. Results Repeated oral gavage of ethanol produced significant locomotor sensitization, with those mice increasing total distance traveled by 2-fold. The locomotor response to caffeine, while significantly greater than vehicle gavage, did not change with repeated exposure. On the other hand, repeated gavage of caffeine/ethanol combination produced a substantial increase in total distance traveled after repeated exposure (~4-fold increase). After repeated ethanol exposure, there was significant tolerance to ethanol in the conditioned taste aversion and parallel rod tests. However, neither a history of caffeine exposure nor including caffeine influenced ethanol-induced conditioned taste aversion. Interestingly, a history of caffeine exposure increased the ataxic response to the caffeine/ethanol combination and appeared to reduce the ataxic response to high doses of ethanol. Conclusion The data support the general hypothesis that repeated exposure to caffeine influences the response to ethanol. Together with previously published work, these data indicate that caffeine influences some ethanol-related behaviors, notably locomotion and ataxia, but appears not to influence the expression of conditioned behaviors.

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Section: Introductionmentioning

confidence: 99%

Sensitization and Tolerance Following Repeated Exposure to Caffeine and Alcohol in Mice

May

Haun

Griffin

2015

Alcohol Clin Exp Res

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“…Behavioral sensitization has two distinct phases, induction and expression, marked, respectively, by neural changes that occur in VTA and long-term changes in neuronal function ( Camarini and Pautassi, 2016 ). The behavioral sensitization paradigm has been used to investigate the abuse-related behavioral effects of different drug classes ( Marinho et al, 2015 ; McGovern et al, 2015 ; Oliveira-Lima et al, 2015 ). The expression of behavioral sensitization induced by opioids seems to involve a hypersensitivity of neurons and dopaminergic receptors located in the mesoaccumbens region ( Vanderschuren et al, 1999 ).…”

Section: Discussionmentioning

confidence: 99%

Context-dependent effects of the CB1 receptor antagonist rimonabant on morphine-induced behavioral sensitization in female mice

Marinho

Oliveira-Lima²,

Reis³

et al. 2023

Front. Pharmacol.

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Introduction: The endocannabinoid system has been implicated in the neurobiology of opioid use disorder. While the CB1 receptor antagonist rimonabant has been shown to block some of the behavioral effects of opioids, studies suggest that the treatment environment (i.e., receiving treatment in the drug-associated environment, and/or novelty) can influence its effects. In the present study, we investigated the role of the treatment environment in the effects of rimonabant on the expression of morphine-induced behavioral sensitization.Methods: Adult female Swiss mice were submitted to a behavioral sensitization protocol, during which they received morphine (20 mg/kg, i.p.) in the open-field apparatus, and were subsequently treated with vehicle or rimonabant (1 or 10 mg/kg, i.p.) either in the open-field, in the home-cage or in an activity box (novel environment). The expression of conditioned locomotion (increased locomotor activity in the open-field apparatus in the absence of morphine) and of morphine-induced behavioral sensitization (increased locomotor activity in animals sensitized to morphine) was evaluated during asubsequent saline and morphine challenge, respectively.Results: Animals treated with morphine expressed behavioral sensitization, showing a significant increase in locomotor activity over time. Animals sensitized to morphine and treated with vehicle in the home-cage expressed conditioned locomotion, an effect that was blocked by home-cage treatment with rimonabant. During a saline challenge, only animals sensitized to morphine and treated with saline in the home-cage expressed morphine-induced conditioned locomotion. All morphine-treated animals that received saline during the treatment phase (control groups) expressed behavioral sensitization during the morphine challenge. Treatment with rimonabant in the open-field and in the activity box, but not in the home-cage, blocked the expression of morphine-induced behavioral sensitization.Discussion: Our findings suggest that CB1 receptor antagonism can modulate conditioned responses to morphine even when administered in the home-cage. However, exposure to the drug-associated environment or to a novel environment is necessary for the expression of rimonabant’s effects on morphine-induced behavioral sensitization during a morphine challenge.

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Generalization of a positive-feature interoceptive morphine occasion setter across the rat estrous cycle

Peart,

Claridge,

Karlovcec

et al. 2024

Hormones and Behavior

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Influence of sensitization on the discriminative stimulus effects of methylphenidate in mice

Cited by 3 publications

References 68 publications

Sensitization and Tolerance Following Repeated Exposure to Caffeine and Alcohol in Mice

Sensitization and Tolerance Following Repeated Exposure to Caffeine and Alcohol in Mice

Context-dependent effects of the CB1 receptor antagonist rimonabant on morphine-induced behavioral sensitization in female mice

Generalization of a positive-feature interoceptive morphine occasion setter across the rat estrous cycle

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