Influence of Sensory Neurons Isolated From Central Nervous System on Maintenance of Taste Buds and Regeneration of Barbels in the Catfish, <i>Ameiurus nebulosus</i>

Kamrin, Robert P.; Singer, Marcus

doi:10.1152/ajplegacy.1953.174.1.146

Cited by 43 publications

(4 citation statements)

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“…An uninterrupted connection to the taste buds is necessary for their maintenance and function (cf. Similar conclusions were drawn by Kamrin and Singer (1953) from data in catfish and by Zalewski in the rat (1969). However, an uninterrupted connection with the brain is not necessary.…”

Section: Discussionsupporting

confidence: 83%

“…Interruption of the axons between CNS and the ganglion will not cause their disappearance, though of course it will abolish the ability of the animal to sense taste. Similar conclusions were drawn by Kamrin and Singer (1953) from data in catfish and by Zalewski in the rat (1969). The results do not allow conclusions on the type of substance that is transported but it seems evident from other studies (Zalewski 1968, 1970, Farbman 1972) that the cell bodies of the taste neurons synthesize a special type of substance either this synthesis occurs under the influence of some factor produced in the epithelium of the tongue and transported to the nerve cell bodies (Zalewski 1973) or is synthesized independant of the periphery.…”

Section: Discussionsupporting

confidence: 83%

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Decline and disappearance of taste response after interruption of the chorda tympani proper nerve of the rat

Hellekant

Gopal²,

Ninomiya³

1979

Acta Physiologica Scandinavica

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The response amplitude in the chorda tympani proper nerve of rats to taste stimulation has been studied at different times after interruption of the nerve in the middle ear. The results show that the reponse in the nerve declined and disappeared completely within 15 h after the nerve was interrupted. As a first sign of deteriorating function a stage of hypersensitivity was observed. Results obtained during applications of local anesthetic or colchicine and section at different distances from the tongue indicate that the decreased response was the result of an interruption of axoplasmic flow from the nerve cell bodies in the geniculate ganglion to the taste buds.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%

Decline and disappearance of taste response after interruption of the chorda tympani proper nerve of the rat

Hellekant

Gopal²,

Ninomiya³

1979

Acta Physiologica Scandinavica

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“…Likewise, most (75%) of these latter studies examined the 1-5 week postoperative interval. Some authors account for the scant buds remaining during the degenerative period either as midline-region buds receiving contralateral innervation (e.g., Cheal and Oakley, 1977;Hayes and Elliott, 1942;Guth, 1958;State et al, 1982;Whiteside, 1927) or by the incompleteness of Wallerian degeneration in the sectioned nerve (e.g., Kamrin and Singer, 1953) or by the coincidental occurrence of regeneration when nerve regrowth could not be ruled out (e.g., . In addition, of ten studies reporting presence of buds or bud cells (Cheal and Oakley, 1977;Chelyshev et al, 1982;Farbman, 1969;Fujimoto and Murray, 1970;Kennedy, 1972;Krol and Dubbeldam, 1979;Olmsted, 1921Olmsted, ,1922Sloan et al, 1983;Whitehead et al, 1985), nine examined tissue between 1 and 15 postoperative days, which may be early for complete degeneration to have occurred, under their experimental conditions.…”

mentioning

confidence: 99%

Long‐term effects of gustatory neurectomy on fungiform papillae in the young rat

Ganchrow

1989

Anat. Rec.

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Recent evidence from mature hamster fungiform papillae indicates that following denervation taste buds are present from 21 to 330 days in the absence of discernible intragemmal nerve fibers. In contrast, most prior taste bud degeneration studies focused on shorter survival times. The present inquiry in young rats examined the issue of postneurectomy buds, in which regeneration of the resected chorda tympani or facial nerves was prevented and anterior tongue tissue examined over a range of relatively long survival times (30-90 days). Conditions for observing potential taste buds used three histologic stains and a definition of the taste bud not necessarily requiring pore identification. In each case, serial section examination of the anterior-most 2-3 mm of lingual epithelium revealed 29-56 bud-containing fungiform papillae on the unoperated side. In contrast, ipsilateral to the neurectomy, only zero-7 medially-placed, mature-looking buds were observed per case, as well as zero-3 more laterally situated fungiform papillae containing small clusters of cells in basal epithelium that lacked the vertical organization and cytoplasmic staining intensity of mature taste buds. These cell aggregates were distributed evenly across survival time and stain used. Therefore, in young rats following gustatory neurectomy, longer survival times, per se, would not appear to be a prerequisite for sustaining fungiform taste buds. The appearance of "midline" buds postsurgery may be attributed to either normal contralateral or a net bilateral innervation, and/or ipsilateral denervation and bud loss inducing neural sprouting from the contralateral side.

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“…It was assumed that the stimulation increased the utilization of the existing neurohumoral factor and thus com pelled an earlier breakdown and elimination of dependent sense organs. Kamarin and Singer [1953] reported that nerve transection proximal to the cell body did not result in degeneration of taste buds. They pointed out that the neurohumoral substance was formed by the cell body from which it passed through the axons to the nerve terminals.…”

Section: Discussionmentioning

confidence: 99%

Effect of the length of the distal stump of transected nerve upon the rate of degeneration of taste buds

State¹,

Dessouky²

1977

Cells Tissues Organs

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The present work was carried out to study the effect of the length of the distal stump of transected nerve upon the rate of degeneration and the time course of disappearance of mammalian taste buds. Twelve adult rabbits were anaesthetized and the glossopharyngeal nerves of both sides were exposed and transected so as to leave a long distal stump on the right and a short one on the left side. The animals were sacrificed at different post-operative periods ranging from 2 to 14 days and the circumvallate and foliate papillae of both sides were examined. The taste buds on the side of the short distal stump always showed a greater decrease in number, size and cell contents than those of the side of the long distal stump. The taste buds on the side of the short distal stump disappeared earlier than those of the side of the long distal stump. Vallate taste buds disappeared earlier than the foliate: possible reasons for this were put forwards. The validity of the neurohumoral theory to the mammalian taste buds was discussed.

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Influence of Sensory Neurons Isolated From Central Nervous System on Maintenance of Taste Buds and Regeneration of Barbels in the Catfish, Ameiurus nebulosus

Cited by 43 publications

References 0 publications

Decline and disappearance of taste response after interruption of the chorda tympani proper nerve of the rat

Decline and disappearance of taste response after interruption of the chorda tympani proper nerve of the rat

Long‐term effects of gustatory neurectomy on fungiform papillae in the young rat

Effect of the length of the distal stump of transected nerve upon the rate of degeneration of taste buds

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