Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women

Abstract

The association between mean arterial blood pressure (MAP) and hematocrit (Hct) as a surrogate for blood viscosity was investigated in a young (average 20.0±2.3 years), healthy population of 174 men and 442 women. Health status was assessed by clinical examination and serological evaluation. Individuals with severe anemia or hemoconcentration, prior traumas or major surgical intervention, smokers, and pregnant or lactating women were excluded from the study. The MAP/Hct association was positive and significant (P=0.04) for women and negative, albeit not significantly so, for men. The MAP/Hct association was also evaluated in subgroups of the same population with a progressive step-by-step exclusion of: individuals with cholesterol >200 mg/dL; triglycerides >200 mg/dL; body mass index >25 kg/m2; and glucose >100 mg/dL. This consecutively reduced the strength of the positive MAP/Hct association in women, which became negative – although not significantly so – when all anomalously high factors were excluded. The same trend was found in men. Our study indicates that previously reported positive trends in the relationship between the MAP and Hct in the population are not present in a young, healthy population of men or women that excludes individuals with the confounding factors of above normal serological values and BMI.

Emerging Microfluidic Devices for Sample Preparation of Undiluted Whole Blood to Enable the Detection of Biomarkers

“…Some plasma proteins, like fibrinogen and abnormal immunoglobulins, can cause RBC aggregation that also increases blood viscosity, which is commonly observed in inflammatory disorders, ischemic heart disease, plasma cell dyscrasias, cold hemolytic syndrome, and COVID-19 patients. − Other factors such as sex, medication, and BMI can also affect blood viscosity and flow. ,− …”