Influence of Serotonin on the Glutamate-Induced Excitations of Secondary Vestibular Neurons in the Rat

Volsi, Guido Li; Licata, F.; Fretto, Giovanna; Mauro, Michela Di; Santangelo, F

doi:10.1006/exnr.2001.7804

Cited by 16 publications

(17 citation statements)

References 84 publications

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“…As already cited, in the motor system 5-HT either enhances [80,82,106,119,168,187] or depresses [61,75,102,106,107,118] glutamate-mediated transmission in distinct structures. Also for GABA-mediated transmission either enhancement [39,44,108] or decrease [36,108] by 5-HT have been observed in structures controlling movement.…”

Section: Role In Motor Controlmentioning

confidence: 76%

“…The interplay between 5-HT and glutamate in vestibular nuclei involved different receptor subtypes: the prevailing action of serotonin was a depression of the NMDA component of glutamate response and such effect was mediated by 5-HT 2 receptors. Conversely, an enhancement of both NMDA and non-NMDA receptor-mediated responses was observed in a minority of cases and was mediated by 5-HT 1A receptors [106]. As to the functional consequences of 5-HT effect, changing the responsiveness of vestibular neurons to glutamate might affect postural balance and ocular movements, the main functions controlled by vestibular nuclei.…”

Section: Modulation Of Glutamate Transmissionmentioning

confidence: 99%

“…With respect to glutamate, 5-HT modulation is often directed to NMDA-mediated effects [61,77,80,106], whose function is related to the inhibitory control of movement [188]. Interestingly, recent studies show that impulsive-type behaviours (such as hyperlocomotion and stereotypy) induced by blockade of NMDA receptors can be attenuated by administration of 5-HT 2A antagonists [24,76], suggesting a possible use of 5-HT 2A receptor antagonists to normalise NMDA receptor hypofunction.…”

Section: Role In Motor Controlmentioning

confidence: 99%

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Serotonin as a Modulator of Glutamate- and GABA-Mediated Neurotransmission: Implications in Physiological Functions and in Pathology

Ciranna

2006

272

170

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Abstract:The neurotransmitter serotonin (5-HT), widely distributed in the central nervous system (CNS), is involved in a large variety of physiological functions. In several brain regions 5-HT is diffusely released by volume transmission and behaves as a neuromodulator rather than as a "classical" neurotransmitter. In some cases 5-HT is co-localized in the same nerve terminal with other neurotransmitters and reciprocal interactions take place. This review will focus on the modulatory action of 5-HT on the effects of glutamate and -amino-butyric acid (GABA), which are the principal neurotransmitters mediating respectively excitatory and inhibitory signals in the CNS. Examples of interaction at preand/or post-synaptic levels will be illustrated, as well as the receptors involved and their mechanisms of action. Finally, the physiological meaning of neuromodulatory effects of 5-HT will be briefly discussed with respect to pathologies deriving from malfunctioning of serotonin system.

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Section: Role In Motor Controlmentioning

confidence: 76%

Section: Modulation Of Glutamate Transmissionmentioning

confidence: 99%

Section: Role In Motor Controlmentioning

confidence: 99%

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Serotonin as a Modulator of Glutamate- and GABA-Mediated Neurotransmission: Implications in Physiological Functions and in Pathology

Ciranna

2006

272

170

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“…In terms of understanding the potential functional significance of serotonergic modulation of the VNC, it is important to note that serotonin has been demonstrated to negatively modulate the effects of glutamate on the majority (86%) of VNC neurons [16]. Since glutamate is the major excitatory neurotransmitter in the VNC and the neurotransmitter mediating input from the vestibular nerve [11], this suggests that the impact of changes in serotonin levels on VNC neurons could be dramatic.…”

Section: Possible Effects Of Ssri Discontinuation On the Vestibular Smentioning

confidence: 99%

A possible explanation for dizziness following SSRI discontinuation

Smith

Darlington

2010

Acta Oto-Laryngologica

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Dizziness is the most commonly reported symptom of abrupt discontinuation from the selective serotonin reuptake inhibitor (SSRI) category of antidepressants. The reported dizziness is exacerbated by even slight head movement, and therefore is likely to be vestibular in origin. The SSRIs most implicated are those with short half-lives and which are most selective for serotonin (as opposed to noradrenaline), e.g. paroxetine and sertraline. Since the vestibular nucleus complex (VNC) has an abundance of serotonin receptors, the abrupt withdrawal from an SSRI is likely to have a substantial impact on the electrophysiological activity of neurons within it. Here we suggest that the abrupt withdrawal from an SSRI is likely to cause a sudden decrease in serotonin in the VNC, which will disrupt the function of VNC neurons bilaterally, causing dizziness without vertigo.

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“…Neurophysiologic studies support the use of serotonergic agents for chronic subjective dizziness. Serotonin alters the response patterns of motion‐sensitive neurons in the vestibular nuclei, 5 inferior olive, 6 and midline cerebellar nuclei 6 . Serotonin also modulates neural activity in the central nucleus of the amygdala, which is reciprocally connected to the central vestibular nuclei and autonomic centers in the brainstem 7 …”

Section: Introductionmentioning

confidence: 99%