Influence of serum amyloid A protein on high-density lipoprotein in chronic inflammatory disease

Kumon, Yoshitaka; Suehiro, Tadashi; Ikeda, Yukio; Yoshida, Kenzo; Hashimoto, Kozo; Ohno, Fumitoshi

doi:10.1016/0009-9120(93)80016-n

Cited by 36 publications

(15 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We have previously reported that plasma SAA concentrations in patients with rheumatic diseases including RA were highly marked as compared with healthy controls [19]. In the present study, SAA levels in plasma and synovial fluid were significantly higher in RA patients than in OA patients.…”

Section: Discussionsupporting

confidence: 50%

“…SAA is a 12,000 MW protein which is produced in the liver and secreted to peripheral blood [17,19]. It is considered to be one of acute phase proteins as the production of SAA is stimulated by IL-1, IL-6 and other cytokines during an inflammatory reaction.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, concentrations of serum amyloid A (SAA), which is one of acute phase proteins [17][18][19], were measured in both plasma and in synovial fluid as an indicator of inflammation.…”

Section: Corticotropinmentioning

confidence: 99%

See 2 more Smart Citations

Differential Changes of Corticotropin Releasing Hormone (CRH) Concentrations in Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis (RA).

et al. 1996

Self Cite

View full text Add to dashboard Cite

Abstract.Corticotropin releasing hormone (CRH) and ACTH concentrations in plasma and CRH and IL-6 concentrations in synovial fluid in patients with rheumatoid arthritis (RA) were examined to clarify the relationship between cytokines and the hypothalamic-pituitary-adrenal axis (HPA axis).Concentrations of serum amyloid A protein (SAA), one of the acute phase proteins, were also measured as an indicator of inflammation. CRH and IL-6 concentrations in synovial fluid were higher in RA patients than in control patients (osteoarthritis, OA). Plasma ACTH and CRH levels were significantly lower in RA patients than in OA patients. This suggests that CRH secretion in synovial fluid is regulated differently from plasma CRH secretion, as CRH levels in synovial fluid and plasma showed opposite changes in RA patients.SAA levels were positively correlated with the levels of CRH or IL-6 in synovial fluid, whereas there was no correlation between CRH and IL-6 levels. The results suggest that CRH and IL-6 play important independent roles in producing SAA in synovial fluid.

show abstract

Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Differential Changes of Corticotropin Releasing Hormone (CRH) Concentrations in Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis (RA).

et al. 1996

Self Cite

View full text Add to dashboard Cite

show abstract

“…Por el contrario, en condiciones normales, las concentraciones de apoSAA dentro de las HDL son muy bajas ( 22 ). Durante la respuesta de fase aguda, se ha demostrado una correlación inversa entre el contenido de apoA-I, apoA-II y colesterol-HDL con las concentraciones séricas de apoSAA ( 23,24 ). También se ha observado un catabolismo acelerado de las partículas de HDL ricas en apoSAA ( 25,26 ).…”

Section: Introductionunclassified

Colesterol y triglicéridos como marcadores bioquímicos del estado de la enfermedad del paciente con leucemia linfocítica aguda

Guzman

Sandoval

2013

An Fac med

View full text Add to dashboard Cite

ResumenObjetivo: Determinar la relación de los niveles séricos de colesterol y triglicéridos con el estado de respuesta al tratamiento quimioterápico de inducción de pacientes con leucemia linfocítica aguda. Material y Métodos: La muestra la conforman 25 pacientes de 2 a 18 años de edad, admitidos al Instituto de Enfermedades Neoplásicas con un diagnóstico reciente de leucemia linfocítica aguda; determinándose en ellos sus concentraciones séricas de colesterol total, colesterol-HDL, colesterol-LDL y triglicéridos, antes y después de la primera fase de la quimioterapia de inducción. Resultados: Solamente 23 pacientes respondieron al tratamiento y en ellos observamos un incremento de 19,24 ± 4,49 mg/dL a 46,84 ± 15,38 mg/dL para el colesterol-HDL; y un descenso de 153,66 ± 36,39 mg/dL a 79,79 ± 34,53 mg/dL para los triglicéridos (p<0,0001). Por el contrario, en los pacientes que no respondieron al tratamiento, se obtuvo un incremento de 14,64 ± 2,46 mg/dL a 23,13 ± 14,23 mg/dL para el colesterol-HDL y un incremento de 121,88 ± 0,56 mg/dL a 161,01 ± 75,25 mg/dL para los triglicéridos. Conclusión: Las concentraciones séricas de colesterol y triglicéridos se relacionan con el estado de la enfermedad del paciente con leucemia linfocítica aguda. Proponemos a estos metabolitos, como marcadores bioquímicos en el seguimiento clínico de esta enfermedad. Palabras clave: Hipocolesterolemia; lipoproteinas del colesterol HDL; lipoproteinas del colesterol LDL; leucemia linfocítica aguda; triglicéridos.Cholesterol and triglycerides as biochemical markers of the state of the patient's illness with acute lymphocytic leukemia Abstract Objective: To determine the relationship of cholesterol and triglycerides serum levels with the response to induction chemotherapy treatment in patients with acute lymphocytic leukemia. Material and Methods: The sample consisted in 25 patients 2 through 18 years-old admitted to the Neoplasia Diseases Institute with a recent diagnosis of acute lymphocytic leukemia in whom serum concentrations of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides were determine, before and after the first phase of the induction chemotherapy. Results: Only 23 patients responded to the treatment and in them we observe an increment from 19,24 ± 4,49 mg/dL to 46,84 ± 15,38 mg/dL for the HDL-cholesterol, and a descent from 153,66 ± 36,39 mg/dL to 79,79 ± 34,53 mg/dL for the triglycerides (p<0,0001). On the contrary, in the patients that didn't respond to the treatment, an increment was obtained from 14,64 ± 2,46 mg/ dL to 23,13 ± 14,23 mg/dL for HDL-cholesterol and an increment from 121,88 ± 0,56 mg/dL to 161,01 ± 75,25 mg/dL for triglycerides. Conclusion: Serum concentrations of cholesterol and triglycerides are correlated with the state of the patient's illness with acute lymphocytic leukemia. We propose these metabolites as biochemical markers in the clinical pursuit of this illness.

show abstract

“…(Gabay & Kushner 1999;Bahk et al 2010). The conversion of SAA to apolipoprotein A-I and A-II increases the catabolism of HDL, and changes the distribution of HDL by inhibiting lecithinÀcholesterol acetyltransferasemediated lipidation of serum cholesterol (Steinmetz et al 1989;Kumon et al 1993;Salazar et al 2001). …”

Section: Relationship Between the Urine Protein Profile And Lipid Metmentioning

confidence: 99%

Mass spectral analysis of urine proteomic profiles of dairy cows suffering from clinical ketosis

Sheng

Xia³

et al. 2015

Veterinary Quarterly

View full text Add to dashboard Cite

show abstract

Influence of serum amyloid A protein on high-density lipoprotein in chronic inflammatory disease

Cited by 36 publications

References 25 publications

Differential Changes of Corticotropin Releasing Hormone (CRH) Concentrations in Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis (RA).

Differential Changes of Corticotropin Releasing Hormone (CRH) Concentrations in Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis (RA).

Colesterol y triglicéridos como marcadores bioquímicos del estado de la enfermedad del paciente con leucemia linfocítica aguda

Mass spectral analysis of urine proteomic profiles of dairy cows suffering from clinical ketosis

Contact Info

Product

Resources

About