Influence of serum luteinising hormone concentrations on ovulation, conception, and early pregnancy loss in polycystic ovary syndrome

Abstract

repaired or not, does not preclude patients from holding an ordinary driving licence." Possibly this statement should be extended to include suggestions relating to screening of patients of the relevant age group and sex to identify such high risk disease.

Dynamics of pituitary down-regulation and ovarian response to controlled stimulation in in vitro fertilization cycles

“…An increased risk of early pregnancy loss has also been suggested (2). These findings are in agreement with the LH threshold theory but at odds with previous evidence that higher LH levels in the later phase of follicular development led to increased pregnancy loss (3,4). Consequently, the following LH ceiling theory was postulated: that above a certain level, LH is detrimental to follicular maturation and growth in the late follicular phase (5).…”

“…The following primary outcomes were measured in this study: [1] The LH levels before and after buserelin administration on cycle days 2, 5, and 9; [2] the relationship between the percentage of LH increase or ⌬ LH (postbuserelin LH-prebuserelin LH/prebuserelin LH ϫ 100) and the prebuserelin LH levels on days 2, 5, and 9; and [3] the effect of the prebuserelin LH level and ⌬ LH on the number of follicles, the number of oocytes, peak E 2 level, total gonadotropin dose, and duration of stimulation. Statistical analysis was carried out with a SPSS software package (Chicago, IL, USA).…”

Consensus on infertility treatment related to polycystic ovary syndrome

“…The mechanisms include premature oocyte maturation through inhibition of oocyte maturation inhibitor (83) and deleterious LH effect on granulosa cell steroidogenesis (84,85). In addition, elevated LH levels may be associated with an increased pregnancy loss (86)(87)(88)(89), although more recent data are not consistent with this assumption (10,90,91).…”

Functional characterization of a natural variant of luteinizing hormone

“…In the male, androgens produced by Leydig cells in response to LH initiate spermatogonial cell formation and spermatogenesis in the Sertoli cells of testes, and development of male secondary sexual characteristics. From a clinical perspective, any defect in the LH affecting its bioactivity is thought to induce clinical abnormalities (Homburg et al 1988;Weiss et al 1992;Balen et al 1993;Risma et al 1995).…”