Influence of sex, age and thyroid function indices on dual-energy computed tomography-derived quantitative parameters of thyroid in patients with or without Hashimoto’s thyroiditis

Abstract

Purpose To study the influence of sex, age and thyroid function indices on dual-energy computed tomography (DECT)-derived quantitative parameters of thyroid in patients with or without Hashimoto’s thyroiditis (HT). Material and methods A total of 198 consecutive patients who underwent DECT scan of neck due to unilateral thyroid lesions were retrospectively enrolled. Iodine concentration (IC), total iodine content (TIC) and volume of normal thyroid lobe were calculated. Influences of sex, age and thyroid function indices on DECT-derived parameters in overall study population, subgroup patients with, and those without HT were assessed using Mann–Whitney U test, Student’s T-test, and Spearman correlation analyses, respectively, as appropriate. Results HT group showed significantly lower IC and TIC, while higher volume than No-HT group (all p < 0.001). The volume was larger in male than that in female in overall study population and No-HT group (p = 0.047 and 0.010, respectively). There was no significant difference in any DECT-derived parameters between low (≤ 35 years) and high (> 35 years) age group in all three groups (all p > 0.05). TPOAb and TgAb correlated positively with IC and TIC, and negatively with volume in overall study population (all p < 0.05). TPOAb and TgAb also correlated positively with IC in HT group (p = 0.002 and 0.007, respectively). Conclusion DECT-derived parameters of thyroid differed significantly between patients with and without HT. Sex and thyroid function indices could affect the DECT-derived parameters. Aforementioned physiological factors should be considered when analyzing the DECT-derived parameters of thyroid.

Correlation between Interleukin-23, Autoantibodies and Thyroid Profile in a Sample of Iraqi Patients with Hashimoto’s Thyroiditis

“…As long as the P-value is 0.340, there was no statistically significant difference between the groups. This outcome was consistent with that of Geng and colleagues, who found no difference between the HT and non-HT groups at P>0.05 [36].…”

Helicobacter pylori infection increases the risk of thyroid nodules in adults of Northwest China

“…Ionizing radiation exposure and genetic predisposition are reported to be two major risk factors associated with TNs development in children and adolescents (Bauer, 2019). A combination of dietary habits (iodine intake) and psychosocial factors also affect the occurrence of TNs in the general population (Geng et al, 2023). The traditional risk factors for TNs in Chinese population usually include age, female gender, body mass index (BMI), blood pressure, uric acid, fasting glycemia, etc.…”

High rates of aggressive features in young Vietnamese females with papillary thyroid carcinoma: Associations with preoperative risk factors

“…Similarly, reported cervical lymph node metastasis rates range from 15%-90%, reflecting differences in study populations, disease staging, and diagnostic criteria [7][8][9] . The factors driving this heterogeneity, particularly the independent contributions of variables like age, sex, and cytologic findings, remain poorly characterized [10,11] . Importantly, clinical management differs considerably between regions.…”