Influence of sex on development of thrombosis in patients with COVID-19: From the CLOT-COVID study

Therapeutic-Dose vs. Prophylactic-Dose Anticoagulation Therapy for Critically Ill Patients With COVID-19 in a Practice-Based Observational Study

“…The design of the study has been reported in detail. 15,16 In the current study, we identified 229 patients with severe COVID-19 on admission who required mechanical ventilation or extracorporeal membrane oxygenation (ECMO), 14,17 after excluding 1,738 patients with mild COVID-19 on admission who did not require oxygen administration and 927 patients with moderate COVID-19 on admission who required oxygen administration (Figure). We further excluded 4 patients who did not receive prophylactic anticoagula- contrast venography) or by autopsy.…”

Influence of obesity on incidence of thrombosis and disease severity in patients with COVID-19: From the CLOT-COVID study

“…The CLOT-COVID Study (thrombosis and antiCoaguLatiOn Therapy in patients with COVID-19 in Japan Study: UMIN000045800) was a physician-initiated, retrospective, multicenter cohort study involving consecutive hospitalized patients with COVID-19 from 16 centers in Japan between April 2021 and September 2021. The design of the study was previously reported in detail [18] . A total of 2894 consecutive patients who were diagnosed with COVID-19 using a positive polymerase chain reaction test were enrolled through the hospital databases.…”

“…We defined patients who did not require oxygen as mild COVID-19, those who required oxygen as moderate COVID-19, and those who required mechanical ventilation (MV) or extracorporeal membrane oxygenation (ECMO) as severe COVID-19 [18] , [20] , [21] . Pharmacological thromboprophylaxis managements were defined as the usage of any anticoagulants except for their usage for the treatment of thrombosis.…”

Significant Impact of Age on Mortality and Non-significant Impact of Age on Thrombosis and Major Bleeding in Patients with COVID-19: From the CLOT-COVID Study

“…It enrolled 2894 consecutive hospitalized patients diagnosed with COVID-19 infection by a positive polymerase chain reaction test among 16 centers in Japan from April 2021 to September 2021. The design of the study was previously reported in detail 12,13) . All participating centers' relevant review boards or ethics committees (Supplementary Appendix 1) approved…”