Influence of Sex on Outcome Following Transcatheter Aortic Valve Implantation (TAVI): Systematic Review and Meta‐Analysis

Abstract

In treatment with TAVI, there is evidence for a significantly greater overall survival benefit in women over men.

Outcomes in patients undergoing transcatheter aortic valve replacement: a sex-based story of success?

“…In female patients, nontransfemoral access, surgical cutdown, and smaller sheath sizes (median; 22 vs. 24 F) were more frequently used. Although the study's results are not surprising and align with other previous studies (8,14,15), they illustrate the importance of gender variability in TAVR cohorts including a significant number of patients. While female gender has generally worse clinical outcomes as men in trials on percutaneous coronary interventions (PCI), coronary artery bypass graft surgery (CABG), and surgical aortic valve replacement (SAVR), it is of interest, that like in various other studies, female gender beats male gender in terms of an improved one year survival rate which this study underlines.…”

Incidence and prognosis of vascular complications after percutaneous placement of left ventricular assist device

“…This is probably related to the increased incidence of vascular complications in patients with smaller arteries. 29,30 None of the vascular complications in this study were attributed to thromboembolic events, and all originated from injury to the artery or occlusion from the large cannula. Patients in shock and on inotropic support also showed a significantly higher incidence of limb ischemia, probably because they were hypoperfused to begin with, and as may be expected, the Impella device was placed for a longer time.…”

Time course of the survival advantage of transcatheter over surgical aortic valve replacement: Interplay between sex and patient risk profile

“…Previous meta‐analyses and a retrospective study from the Society of Thoracic Surgeons/American College of Cardiology (STS/ACC) Transcatheter Valve Therapy (TVT) Registry pulling data of more than 23,000 patients (49.9% women) showed a survival benefit in women treated with TAVR compared to men, despite older age and higher rates of vascular complications, bleeding events, and strokes. This benefit was marginally observed perioperatively .…”