Influence of Shape Factors on Kinetics of Drug Release from Matrix Tablets I: Theoretical

Cobby, J. M.; Mayersohn, Michael; Walker, George

doi:10.1002/jps.2600630516

Cited by 93 publications

(29 citation statements)

References 22 publications

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“…A kinetic equation 16 with a cubic form had been derived to describe the diffusion control release behaviors of drug for a porous matrix (M t /M 0 < 60%):…”

Section: Diffusion Coefficientmentioning

confidence: 99%

Preparation of poly(acrylic acid‐co‐acrylamide)/kaolin and release kinetics of urea from it

Liang

Liu

2007

J of Applied Polymer Sci

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A series of poly(acrylic acid-co-acrylamide)/ kaolin [poly(AA-co-Am)/kaolin] composites were prepared by aqueous solution copolymerization of partially neutralized acrylic acid and acrylamide in the presence of kaolin nanopowder, which was synthesized to act as a release carrier of urea fertilizer. The superabsorbent composite was swollen in aqueous solution of urea to load urea, and the effect of urea concentration on the swelling was investigated. Furthermore, the effects of the contents of crosslinker, kaolin, and acrylamide, the neutralization degree of acrylic acid, and temperature, pH, and ionic strength of release medium on water absorbency and diffusion coefficient of urea release from poly(AA-co-Am)/kaolin were studied systematically. It was found that urea loading percentage could be adjusted by urea concentration of swelling medium, and urea diffusion coefficient could be regulated through the contents of crosslinker, kaolin, and acrylamide, and the neutralization degree of acrylic acid. Additionally, temperature and ionic strength of release medium may also affect the urea release process. The conclusions obtained could provide theoretical basis for urea diffusion behavior in superabsorbent used in agriculture.

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“…A kinetic equation 16 with a cubic form had been derived to describe the diffusion control release behaviors of drug for a porous matrix (M t /M 0 < 60%):…”

Section: Diffusion Coefficientmentioning

confidence: 99%

Preparation of poly(acrylic acid‐co‐acrylamide)/kaolin and release kinetics of urea from it

Liang

Liu

2007

J of Applied Polymer Sci

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“…The fraction of released gentamicin versus the square root of time can be fitted to a third order polynomial, corresponding with the model proposed by Cobby et al 22 for this kind of system (heterogeneous, insoluble matrix-partially in this case-with pores and canals, and parallelepiped-shaped with all the surfaces exposed to the medium).…”

Section: Gentamicin Releasementioning

confidence: 99%

In vitro bioactivity and gentamicin release from glass-polymer-antibiotic composites

Ragel

Vallet‐Regí

2000

J. Biomed. Mater. Res.

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Composite materials have been prepared from bioactive glass powders in the SiO(2)-CaO-P(2)O(5) system, a biodegradable polymer [poly(L-lactic acid) (PLA)], a biostable polymer [polymethylmethacrylate (PMMA)], and an antibiotic [gentamicin]. The purpose of such composites is to obtain implantable materials that are able to lead to bone growth and also can, at the most critical inflammation-infection step, release an antibiotic. X-ray diffraction, scanning electron microscopy, X-ray energy dispersive spectroscopy, and FTIR analyses after different soaking periods in SBF demonstrated the growth of an apatite-like layer on the composite surface. Therefore the bioactive glass-polymer-antibiotic combination used in this work does not inhibit the glass bioactivity. The release of gentamicin after a soaking of the materials in SBF was followed by UV-visible spectroscopy. A fast initial release during the first 10 h of soaking, followed by a controlled release of the drug was observed.

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“…Effect of different polymers on the release profile of Nifedipine was studied. In formulations F1, F2, F3 different concentrations of HPMCE5 were used [9]. The release of the drug from the tablet was up to 20 hours only, so these polymers (with in this concentrations) not having the capacity to extend the release up to 24 hours (Table 5).…”

Section: Dissolution Profile Of Formulations F1-f9mentioning

confidence: 99%

Formulation and Evaluation of Sustained Release Matrix Tablets of Nifedipine

Berkachy¹

2015

Ann Clin Lab Res

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Influence of Shape Factors on Kinetics of Drug Release from Matrix Tablets I: Theoretical

Cited by 93 publications

References 22 publications

Preparation of poly(acrylic acid‐co‐acrylamide)/kaolin and release kinetics of urea from it

Preparation of poly(acrylic acid‐co‐acrylamide)/kaolin and release kinetics of urea from it

In vitro bioactivity and gentamicin release from glass-polymer-antibiotic composites

Formulation and Evaluation of Sustained Release Matrix Tablets of Nifedipine

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