This article presents a numerical analysis of multi-phase flow with powerful swirling streams in a cylindrical separator equipped with two vortex generators in an attempt to predict the separation efficiency of an air-water mixture. New design of a cylindrical separator is introduced for air-water mixture.The mixture multiphase and large eddy simulation (LES) turbulence models were applied. Images that concern velocity field, pressure, and volume fraction are introduced. Air phase is trapped and localized along the centerline of the separator and then migrates toward the upper exit hole, while water phase is distributed and rotated along the wall, then confined at the mid-separator due to two strong clock-wise centrifugal forces before it is expelled through its exit at mid of separator. It was found that the separation efficiency at constant Reynolds number of 8×10 4 with two feeding volume fractions of 95% and 90% are 97.8% and 96.1%, respectively. Also, the separation efficiency at constant feeding volume fraction of 95% with two Reynolds numbers of 2×10 5 and 8×10 4 are 98.6% and 97.8%, respectively. It is revealed that the separation efficiency will increase as the Reynolds number increases and/or increasing the volume fraction.