Influence of simultaneous low amniotomy and oxytocin infusion and other maternal factors on neonatal jaundice: a prospective study.

Transcutaneous Bilirubin Levels in the First 96 Hours in a Normal Newborn Population of ≥35 Weeks' Gestation

“…Therefore, the TSB values obtained after 48 to 72 hours likely represent a biased sample of more-jaundiced infants, and the data from several other studies support this conclusion. [11][12][13][14][15][16][17] In the nomogram of Bhutani et al, 2 the TSB levels reported for the 40th percentile after 48 hours are much higher than the mean TSB levels reported in any previous study, [11][12][13][14][15][16][17] including values for an exclusively breastfed Japanese population. 18 In 6 studies of infants of predominantly northern European origin, 12-17 the mean peak TSB level between days 3 and 6 was 7.1 Ϯ 0.89 mg/dL; in our study, the level at 96 hours was 7.2 Ϯ 3.73 mg/dL (median: 7.7 mg/dL).…”

“…Our mean and median values, however, are quite consistent with most published data for similar populations. [12][13][14][15][16][17] This study has some limitations. It is not a populationbased study, and it represents the data of a single center for a sample of predominately white infants.…”

Vacuum extraction and neonatal jaundice

“…It is interesting to note that fetal scalp damage resulting in neonatal jaundice can be caused also by a fetal ,scalp electrode [7]. The association of oxytocin induction of labor and neonatal jaundice is still a matter of controversy [3,4,5,6,8,10,11,21]. It has been suggested that hyperbilirubinemia may result from an increased rate of red cell breakdown and hemoglobin catabolism secondary to increased intensity of uterine contractions [8] or decreased erythrocyte deformability [3].…”

“…It has been suggested that hyperbilirubinemia may result from an increased rate of red cell breakdown and hemoglobin catabolism secondary to increased intensity of uterine contractions [8] or decreased erythrocyte deformability [3]. Others have speculated that oxytocin induction before the actual start of labor may be associated with a lack of hormonal surge present at spontaneous delivery, and hence a reduced activity of hepatic enzymes involved in bilirubin metabolism [4,5,6]. Our results, in accordance with others [10,11,21], failed to show any positive correlation between oxytocin induction and neonatal hyperbilirubinemia.…”

Bilirubin and protein concentration in cord blood after spontaneous versus induced labor. Correlation to neonatal hyperbilirubinemia.

“…Recent studies [3,5,7,11,13,18] cast doubt on the role of oxytocin per se in this respect, s neonatal hyperbiliruinemia seemed to occur predominantly in oxytocin induced labors s opposed to oxytocin accelerated ones following spontaneous-onset. The role of fetal hepatic maturation has been implicated in this context [7].…”