Air-to-water heat pumps (AWHPs) is a very good option for efficient heating in the residential and commercial building sectors. Their performance and therefore the use of primary energy and CO2 gas emissions are affected by various factors. The aim of this paper is to present a study on the seasonal coefficient of performance in heating (SCOP) of AWHPs, which are available in the Greek market. The sample consists of 100 models in total, offered by 12 manufacturers, in a range of heat pump’s thermal capacity up to 50 kW. The calculation of SCOP values was performed according to the methodology proposed by the EN14825 standard. The results indicate how the heating capacity, the local climate, the supply water temperature, the compressor’s technology, and the control system affect the seasonal performance of the various AWHP models examined. Setting the SCOP ≥ 3 value as a criterion, the analysis that was carried out in four climatic zones A, B, C, and D of Greece, shows that there are many models that meet this criterion, and, in fact, their number increases from the coldest to warmer climates, in combination with lower water supply temperatures to the heating system and a control system with weather compensation.