Influence of Skeletal and Local Bone Density on Dental Implant Stability in Patients with Osteoporosis

Merheb, Joe; Temmerman, Andy; Rasmusson, Lars; Kübler, Alexander C.; Thor, Andreas; Quirynen, Marc

doi:10.1111/cid.12290

Cited by 74 publications

(71 citation statements)

References 26 publications

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“…Osteoporosis may represent a risk for the osseointegration of endosseous implants [6–8] as bone may be too rarefied to offer good implant primary stability, one of the pre-requisites for osseointegration [9]. …”

Section: Introductionmentioning

confidence: 99%

The effect of magnesium on early osseointegration in osteoporotic bone: a histological and gene expression investigation

et al. 2017

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SummaryMagnesium has a key role in osteoporosis and could enhance implant osseointegration in osteoporotic patients. Titanium implants impregnated with Mg ions were installed in the tibia of ovariectomized rats. The release of Mg induced a significant increase of bone formation and the expression of anabolic markers in the peri-implant bone.IntroductionThe success of endosseous implants is highly predictable in patients possessing normal bone status, but it may be impaired in patients with osteoporosis. Thus, the application of strategies that adjuvate implant healing in compromized sites is of great interest. Magnesium has a key role in osteoporosis prevention and it is an interesting candidate for this purpose. In this study, the cellular and molecular effects of magnesium release from implants were investigated at the early healing stages of implant integration.MethodsOsteoporosis was induced in 24 female rats by means of ovariectomy and low-calcium diet. Titanium mini-screws were coated with mesoporous titania films and were loaded with magnesium (test group) or left as native (control group). The implants were inserted in the tibia and femur of the rats. One, 2 and 7 days after implantation, the implants were retrieved and histologically examined. In addition, expression of genes was evaluated in the peri-implant bone tissue at day 7 by means of quantitative polymerase chain reactions with pathway-oriented arrays.ResultsThe histological evaluation revealed that new bone formation started already during the first week of healing for both groups. However, around the test implants, new bone was significantly more abundant and spread along a larger surface of the implants. In addition, the release of magnesium induced a significantly higher expression of BMP6.ConclusionsThese results provide evidence that the release of magnesium promoted rapid bone formation and the activation of osteogenic signals in the vicinity of implants placed in osteoporotic bone.Electronic supplementary materialThe online version of this article (doi:10.1007/s00198-017-4004-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

The effect of magnesium on early osseointegration in osteoporotic bone: a histological and gene expression investigation

et al. 2017

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“…Osteoporosis, characterised by low bone mass and bone deterioration, increases bone fragility and the risk of fracture12. Sex hormones are crucial for maintaining bone mass, and the lack of oestrogen decreases bone mass and increases the risk of osteoporosis.…”

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confidence: 99%

Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats

Hao

et al. 2017

Sci Rep

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The bone mineral deficiency in osteoporosis poses a threat to the long-term outcomes of endosseous implants. The inhibitors of cathepsin K (CatK) significantly affect bone turnover, bone mineral density (BMD) and bone strength in the patients with osteoporosis. Therefore, we hypothesised that the application of a CatK inhibitor (CatKI) could increase the osseointegration of endosseous implants under osteoporotic conditions. Odanacatib (ODN), a highly selective CatKI, was chosen as the experimental drug. Sixteen rats were randomised into 4 groups: sham, ovariectomy (OVX) with vehicle, OVX with low-dose ODN (5 mg/kg) and OVX with high-dose ODN (30 mg/kg). Titanium implants were placed into the distal metaphysis of bilateral femurs of each OVX rat. After 8 weeks of gavaging, CatKI treatment increased the removal torque, BMD and bone-to-implant contact (BIC). Moreover, high-dose CatKI exerted a better influence than low-dose CatKI. Furthermore, CatKI treatment not only robustly suppressed CatK gene (CTSK) expression, but also moderately reduced expression of the osteoblast-related genes Runx2, Collagen-1, BSP, Osterix, OPN, SPP1 and ALP. Thus, CatKI could affect the osteoblast-related genes, although the balance of bone turnover was achieved mainly by CatK inhibition. In conclusion, CatKI prevented bone loss and aided endosseous implantation in osteoporotic conditions.

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“…In previous investigations by this same group 17,18 and other groups, 14,15,19 the relationship between implant stability and different bone and implants variables has been assessed and a correlation already estab- In the scope of those same concerns about the variability of bone density over minute distances, the use of stereolithographical guides offers a greater precision of measurement by allowing a more reliable transcription of implant position but also, depth of insertion, direction, and inclination. This method offers a significantly more accurate planning of the implants locations than the method used previously by our group and which relied on a photographical superposition of radiographs and/or intra oral photographs.…”

Section: Discussionmentioning

confidence: 99%

Relationship of implant stability and bone density derived from computerized tomography images

Merheb

Vercruyssen

Coucke

et al. 2017

Clin Implant Dent Rel Res

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Influence of Skeletal and Local Bone Density on Dental Implant Stability in Patients with Osteoporosis

Cited by 74 publications

References 26 publications

The effect of magnesium on early osseointegration in osteoporotic bone: a histological and gene expression investigation

The effect of magnesium on early osseointegration in osteoporotic bone: a histological and gene expression investigation

Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats

Relationship of implant stability and bone density derived from computerized tomography images

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