Influence of Smoking and Adrenaline (Epinephrine) on the Uterotubal Insufflation Test (Rubin Test)

Neri, Alexander; Eckerling, B

doi:10.1016/s0015-0282(16)37154-0

Cited by 39 publications

(14 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inhalation of smoke has been reported to affect the electrical activity of the rabbit oviduct, 7 to reduce the ratio of ciliated to secretory epithelial cells in the hamster oviduct, and to temporarily influence patency of human Fallopian tube. 9 Despite these findings, the exact mechanism by which smoking leads to tubal ectopic pregnancy remains unknown.…”

mentioning

confidence: 99%

Cotinine Exposure Increases Fallopian Tube PROKR1 Expression via Nicotinic AChRα-7

Shaw

Oliver

Lee

et al. 2010

The American Journal of Pathology

View full text Add to dashboard Cite

Tubal ectopic pregnancy (EP) is the most common cause of maternal mortality in the first trimester of pregnancy; however, its etiology is uncertain. In EP, embryo retention within the Fallopian tube (FT) is thought to be due to impaired smooth muscle contractility (SMC) and alterations in the tubal microenvironment. Smoking is a major risk factor for EP. FTs from women with EP exhibit altered prokineticin receptor-1 (PROKR1) expression, the receptor for prokineticins (PROK). PROK1 is angiogenic, regulates SMC, and is involved in intrauterine implantation. We hypothesized that smoking predisposes women to EP by altering tubal PROKR1 expression. Sera/FT were collected at hysterectomy (n ‫؍‬ 21). Serum levels of the smoking metabolite, cotinine, were measured by enzyme-linked immunosorbent assay. FTs were analyzed by q-RT-PCR , immunohistochemistry , and Western blotting for expression of PROKR1 and the predicted cotinine receptor, nicotinic acetylcholine receptor ␣-7 (AChR␣؊7). FT explants (n ‫؍‬ 4) and oviductal epithelial cells (cell line OE-E6/E7) were treated with cotinine and an nAChR␣؊7 antagonist. PROKR1 transcription was higher in FTs from smokers (P < 0.01). nAChR␣؊7 expression was demonstrated in FT epithelium. Cotinine treatment of FT explants and OE-E6/E7 cells increased PROKR1 expression (P < 0.05) , which was negated by cotreatment with nAChR␣؊7 antagonist. Smoking targets human FTs via nAChR␣؊7 to increase tubal PROKR1, leading to alterations in the tubal microenvironment that could predispose to EP.

show abstract

mentioning

confidence: 99%

Cotinine Exposure Increases Fallopian Tube PROKR1 Expression via Nicotinic AChRα-7

Shaw

Oliver

Lee

et al. 2010

The American Journal of Pathology

View full text Add to dashboard Cite

show abstract

“…Neri, The data collected in this and previous studies (Neri & Eckerling, 1969) point to a possible effect of nicotine and adrenaline on tubai motility. Since the time which it takes for the fertilized ovum to reach the uterine cavity is such an important factor, any change may act to prevent implantation and thus influence fertility.…”

Section: Methodsmentioning

confidence: 52%

“…The monkeys were fully mature and had had at least three regular menstruations before the start of the investigation. The menstrual cycles were monitored by vaginal cytology every 2 days (using the criteria of de Allende, Shorr & Hartman, 1945) (Bernhard, 1948), and cigarette smoke inhalation is known to have an effect on the uterotubal activity in the human (Neri & Eckerling, 1969). This fact was attributed mainly to the nicotine effect on the adrenal medulla and on other chromaffin cells outside the medulla which secrete adrenaline.…”

Section: Methodsmentioning

confidence: 99%

“…In view of previous studies in which the inhalation of cigarette smoke was found to have an effect on uterotubal junction activity (Neri & Eckerling, 1969), it was decided to investigate the influence of nicotine on tubai activity in vivo in rhesus monkeys, Macaca mulatta. Monkeys were used since they are the only laboratory animals that have reproductive processes sufficiently similar to those of human beings.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Nicotine on the Motility of the Oviducts in the Rhesus Monkey: A Preliminary Report

Neri¹,

Marcus²

1972

Reproduction

View full text Add to dashboard Cite

Summary. Tubal activity under the influence of nicotine was studied in vivo in six mature rhesus monkeys throughout the various phases of the menstrual cycle, using an open-ended catheter technique. The activity monitoring response during the first half of the menstrual cycle was of two types, an early and a delayed response. The first was of higher tone and amplitude, and the second was followed within 1 to 2 min by complete inhibition of tubal activity which lasted for the next 5 to 30 min. During the second half of the menstrual cycle, intravenous nicotine had no significant effect on tubal tonus and the amplitude was only slightly and occasionally affected. The possible mechanism of action of nicotine, both direct and indirect, on tubal activity is discussed.

show abstract

“…Increased resting uterine tonus in female smokers was described decades ago [89]. Literature on the effect of cigarette smoking on endometrial blood flow reported a significantly lower endometrial and subendometrial vascularity and flow intensity throughout the menstrual cycle in smokers [90], although no such effect was detected during IVF treatments [91].…”

Section: Tobacco and Uterine Receptivenessmentioning

confidence: 99%

Cigarette smoking and IVF

Soares

Melo²

2008

Expert Review of Obstetrics & Gynecology

View full text Add to dashboard Cite

The goal of this article is to present a thorough review of the literature concerning the relationship between cigarette smoking and IVF cycle outcome, as well as the possible mechanisms through which tobacco constituents affect these cycles. Cigarette smoke affects spermatozoa structure and function; sperm DNA is damaged by tobacco compounds. Spermatozoa from smokers have reduced fertilizing capacity and embryos display lower implantation rates. Ovarian aging is accelerated in smokers and oocyte number and maturation are negatively affected by cigarette smoke. Clinical parameters of IVF cycle outcome are worse in female smokers. This is also the consequence of impaired uterine receptiveness.

show abstract

Influence of Smoking and Adrenaline (Epinephrine) on the Uterotubal Insufflation Test (Rubin Test)

Cited by 39 publications

References 12 publications

Cotinine Exposure Increases Fallopian Tube PROKR1 Expression via Nicotinic AChRα-7

Cotinine Exposure Increases Fallopian Tube PROKR1 Expression via Nicotinic AChRα-7

Effect of Nicotine on the Motility of the Oviducts in the Rhesus Monkey: A Preliminary Report

Cigarette smoking and IVF

Contact Info

Product

Resources

About