Influence of smoking and esophageal intubation on esophageal pH-metry

Schindlbeck, Norbert E.; Heinrich, Christine; Dendorfer, Andreas; Pace, F.; Müller-Lissner, S

doi:10.1016/0016-5085(87)90634-2

Cited by 52 publications

(18 citation statements)

References 12 publications

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“…One study found no influence of 24 hours refrainment from smoking on 24-hour pH-measurements of the distal esophagus in 10 smokers with GERS. (22) Another study found no immediate effect of smoking cessation on total esophageal acid exposure in 8 smoking men with moderate to severe endoscopic evidence of GERD. (23) The third study, however, found a reduced distal esophageal acid exposure in 14 smokers with reflux esophagitis who abstained from smoking for 48 hours.…”

Section: Discussionmentioning

confidence: 99%

“…(20,21) However, in the available studies, only the very short-term effect of smoking cessation on GERD outcomes was evaluated. (22)(23)(24) Our hypothesis is that tobacco smoking cessation improves GERS. The aim of this study was to clarify if there is an association between tobacco smoking cessation and improvement in GERS in a large and population-based study with long follow-up.…”

Section: Introductionmentioning

confidence: 99%

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Tobacco Smoking Cessation and Improved Gastroesophageal Reflux: A Prospective Population-Based Cohort Study: The HUNT Study

Ness-Jensen

Lindam

Lagergren

et al. 2014

American Journal of Gastroenterology

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Objective Tobacco smoking increases the risk of gastroesophageal reflux symptoms (GERS), but whether tobacco smoking cessation improves GERS is unclear. The aim of this study was to clarify if tobacco smoking cessation improves GERS. DesignThe study was based on the Nord-Trøndelag health study (the HUNT study), a prospective population-based cohort study conducted from -1997-2009 Norway. All residents of the county from 20 years of age were invited. The study included 29,610 individuals (61% response rate) who reported whether they had heartburn or acid regurgitation. The association between tobacco smoking cessation and improvement in GERS was assessed by logistic regression, providing odds ratios (ORs) with 95% confidence intervals (CIs). The analyses were stratified by antireflux medication, and the results were adjusted for sex, age, body mass index (BMI), alcohol consumption, education, and physical exercise. Subgroup analyses were also stratified by BMI.Results Among individuals using antireflux medication at least weekly, cessation of daily tobacco smoking was associated with improvement in GERS from severe to no or minor complaints (adjusted OR 1.78, 95% CI 1.07 to 2.97), compared with persistent daily smoking. This association was present among individuals within the normal range of BMI (OR 5.67, 95% CI 1.36 to 23.64), but not among overweight individuals. There was no association between tobacco smoking cessation and GERS status among individuals with minor GERS or individuals using antireflux medication less than weekly.  Tobacco smoking is associated with an increased the risk of GERS. Conclusion The effect of tobacco smoking cessation on GERS is not clear. 2) What is new here This study did not find any association between tobacco smoking cessation and improvement in GERS in individuals not using regular antireflux medication. Tobacco smoking cessation was associated with an improvement in severe GERS in individuals of normal weight using regular antireflux medication.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tobacco Smoking Cessation and Improved Gastroesophageal Reflux: A Prospective Population-Based Cohort Study: The HUNT Study

Ness-Jensen

Lindam

Lagergren

et al. 2014

American Journal of Gastroenterology

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“…Recent studies are some what conflicting about the effects of smoking, and its cessation, on oesophageal acid expo sure. but the effects observed would not be expected to determine the presence or absence of reflux disease in any particular patient who smokes [8]. There arc also no convincing data to indicate that cessation of smoking achieves effective relief of reflux-induced symptoms.…”

Section: Treatment Of Dyspepsia Due To Reflux Episodesmentioning

confidence: 93%

Long-Term Aims of Treatment of Reflux Disease, and the Role of Non-Drug Measures

Dent

1992

Digestion

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Recent opinion about the long-term aims of treatment of reflux disease has been influenced substantially by the development of highly effective drugs that have minimal side-effects. The success of these drugs has emphasized the importance of gains in lifestyle resulting from relief of heartburn and other reflux-induced symptoms. Such relief is seldom achieved by traditional non-drug measures, which can also significantly impair lifestyle. In many patients with reflux disease, the effective relief of symptoms is a major aim. Oesophagitis, particularly when severe, carries a risk of developing peptic stricture or Barrett’s oesophagus, but the risk factors associated with the development of these significant complications are not well identified. There is also no direct evidence that successful healing of oesophagitis by drug therapy is associated with prevention of local complications of oesophagitis, although many anecdotes regarding the resolution of peptic stricture by successful anti-reflux surgery support this possibility. Similarly, the linkage between development of Barrett’s oesophagus and severe oesophagitis suggests that in some patients maintained healing of oesophagitis will prevent development or progression of Barrett’s oesophagus. These considerations support the aim of healing of severe oesophagitis (i.e. more than patchy erosions), quite independently of the need to achieve effective symptom relief.

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“…In their population-based study with over 4000 participants, Watanabe et al (24) showed that active smoking was an independent risk factor for GERD development (OR: 1.35, CI: 1.01-1.82). Schindlbeck et al (25) found more reflux episodes in cigarette smokers than non-smokers, but neither smoking history nor being an active smoker had an effect on esophageal acid exposure time.…”

Section: Does a Reduction Occur In The Severity And Development Of Gamentioning

confidence: 96%

The role of lifestyle changes in gastroesophageal reflux diseases treatment

Dağlı

Kalkan

2020

Turk J Gastroenterol

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Influence of smoking and esophageal intubation on esophageal pH-metry

Cited by 52 publications

References 12 publications

Tobacco Smoking Cessation and Improved Gastroesophageal Reflux: A Prospective Population-Based Cohort Study: The HUNT Study

Tobacco Smoking Cessation and Improved Gastroesophageal Reflux: A Prospective Population-Based Cohort Study: The HUNT Study

Long-Term Aims of Treatment of Reflux Disease, and the Role of Non-Drug Measures

The role of lifestyle changes in gastroesophageal reflux diseases treatment

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