Background: The aim of this study was to investigate the relation between tobacco smoking and chemosensory dysfunction in COVID-19 patients in Northwestern Greece. We also aimed to investigate if there is any relation between smoking and the need of hospitalization, in this West Greece population. Methods: We used a questionnaire to select information about patient demographics, medical history, habits such as tobacco smoking and alcohol consumption and reported symptoms, during infection. In this study were included three hundred covid_19 positive patients that were all undergone the RT-PCR test in the University Hospital of Ioannina, Grecce.150 of them recovered at home and 150 patients needed hospitalization. Statistical analysis based on ΙBM-SPSS Statistics 26.0. Results: The highest percentage of patients that were tobacco smokers was found in the subgroup of patients that recovered at home and was about 20%. The lowest percentage was 8% in the subgroup of patients that needed hospitalization. There is statistically difference between the subgroup of patients with use of tobacco smoking and decreased need for hospitalization. Conclusion: There is no relation between chemosensory dysfunction during SARS_COV2 infection and tobacco smoking. There is a statistically significant difference between active smokers with covid_19 infection and decreased risk for hospitalization.