Influence of snoring on microalbuminuria in diabetic patients

Abstract

Prevalence of OSA-related symptoms was very common in diabetic patients and further prospective studies are needed to elucidate the role of OSA's effect on diabetic control and complications.

Simple snoring: Not quite so simple after all?

“…Indeed this has been shown to be the case for OSA (74). Further, snoring has been linked to microalbuminuria -a persistent increase in urinary albumin -an early indicator of diabetes nephropathy (75). Interestingly, one study showed increased prevalence of diabetes in habitual snorers compared to non-snorers in women but not in men, after controlling for BMI and waist circumference (76).…”

Predictors of diabetic nephropathy

“…Based on earlier data identifying obstructive sleep apnea (OSA) and snoring as independent risks for developing insulin resistance [50], a group of investigators studied OSA as an independent risk factor for the development DN and microalbuminuria [51]. It included 237 type 2 diabetic patients, where 60.3% of patients suffered from snoring, while 31.6% complained of excessive daytime sleepiness [51].…”

“…It included 237 type 2 diabetic patients, where 60.3% of patients suffered from snoring, while 31.6% complained of excessive daytime sleepiness [51]. Using both the Berlin Questionnaire [52] and past medical records, patients were classified as having either a high or low pre-test risk for OSA [51].…”

“…It included 237 type 2 diabetic patients, where 60.3% of patients suffered from snoring, while 31.6% complained of excessive daytime sleepiness [51]. Using both the Berlin Questionnaire [52] and past medical records, patients were classified as having either a high or low pre-test risk for OSA [51]. Results showed significantly higher microalbuminuria in patients who snore, reflected by 0.72± 0.2 and 0.25± 0.04 in snorers and non-snorers, respectively (P=0.002) [51], while microalbuminuria was 0.48± 0.9 and 0.37± 0.1 in patients with high and low pre-test risk for OSA, respectively (P=0.385) [51].…”

“…Using both the Berlin Questionnaire [52] and past medical records, patients were classified as having either a high or low pre-test risk for OSA [51]. Results showed significantly higher microalbuminuria in patients who snore, reflected by 0.72± 0.2 and 0.25± 0.04 in snorers and non-snorers, respectively (P=0.002) [51], while microalbuminuria was 0.48± 0.9 and 0.37± 0.1 in patients with high and low pre-test risk for OSA, respectively (P=0.385) [51]. However, the study remained limited by utilizing screening methods instead of the gold standard polysomnography (PSG), a comprehensive recording of the biophysiological changes that occur during sleep.…”