Influence of Social Environmental Factors on Cerebral Circulation and Mental Function in the Normal Aged

Kobayashi, S; Yamaguchi, S; Katsube, Tsuyoshi; Kitani, Mitsuhiro; Okada, Kazunori; Kitamura, J; Tsunematsu, Takeo

doi:10.1159/000409206

Cited by 3 publications

(2 citation statements)

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“…Several investigators now reported that CBF decreases and brain atrophy advances with aging [22,23]. In patients with bradycar dia before the pacemaker implantation, mean rCBF was significantly lower than that of agematched normal subjects [24], These results indicate that chronic low cerebral perfusion may accelerate brain atrophy.…”

Section: It Has Been Reported That Patients With Severe Bradycardia Smentioning

confidence: 97%

Improvement of Cerebral Blood Flow and Cognitive Function following Pacemaker Implantation in Patients with Bradycardia

et al. 1994

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We investigated the effects of pacemaker implantation on cerebral blood flow and cognitive function in 14 severely bra-dycardic patients (mean age 75.2 years). Cerebral blood flow and verbal intelligence improved after the pacemaker implantation. Systolic and mean arterial blood pressure was significantly reduced after the implantation. Changes in cerebral blood flow significantly correlated with changes in heart rate in polynomial regression analysis, but not with changes in cardiac output. Before the implantation, verbal cognitive function was lower in bradycardic patients than in age-matched control subjects, and brain CT showed significant advanced atrophy in these patients. However, verbal cognitive function was also improved after the implantation. Pacemaker implantation in the severe bradycardic elderly should be beneficial not only for cardiac function but also for brain function. We concluded that these results suggest that heart rate is one of the important factors in the regulation of cerebral circulation in patients with severe bradycardia. Pacemaker implantation in the elderly improved quality of life and may prevent mental deterioration.

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Section: It Has Been Reported That Patients With Severe Bradycardia Smentioning

confidence: 97%

Improvement of Cerebral Blood Flow and Cognitive Function following Pacemaker Implantation in Patients with Bradycardia

et al. 1994

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“…The subjects were volunteers who received a mental health screening in our institute [5], No subjects had a history suggesting disease of the central nervous sys tem, and each had a normal neurological examina tion. There was no evidence of dementia or parkin sonism.…”

Section: Methodsmentioning

confidence: 99%

Primitive Reflexes and MRI Findings, Cerebral Blood Flow in Normal Elderly

Kobayashi

Yamaguchi²,

Okada³

et al. 1990

Gerontology

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We studied the relation between primitive reflexes (glabellar, snout and pal-momental) and MRI findings, cerebral blood flow and mental function in 68 normal aged volunteers. One or more of the three primitive reflexes was elicited in 50% of all subjects. The subjects who had the incidental cerebral lesions showed a significantly higher incidence of the primitive reflexes than those without them. However, there was no difference in mean regional cerebral blood flow (rCBF), brain atrophy and intellectual ability between the subjects with primitive reflexes and those without. The primitive reflexes appear in a significant proportion and these reflexes have a significant relationship with incidental cerebral lesions in normal elderly.

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Prospective Study on the Influence of Social Activity on Development of Dementia in the Neurologically Normal Elderly.

Kobayashi¹,

Yamaguchi²,

Koide³

et al. 1994

Jpn. j. geriat

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Influence of Social Environmental Factors on Cerebral Circulation and Mental Function in the Normal Aged

Cited by 3 publications

References 0 publications

Improvement of Cerebral Blood Flow and Cognitive Function following Pacemaker Implantation in Patients with Bradycardia

Improvement of Cerebral Blood Flow and Cognitive Function following Pacemaker Implantation in Patients with Bradycardia

Primitive Reflexes and MRI Findings, Cerebral Blood Flow in Normal Elderly

Prospective Study on the Influence of Social Activity on Development of Dementia in the Neurologically Normal Elderly.

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