Influence of socio-demographic features and apolipoprotein E epsilon 4 expression on the prevalence of dementia and cognitive impairment in a population of 70–74-year olds: The InveCe.Ab study

Guaita, Antonio; Vaccaro, Roberta; Davin, Annalisa; Colombo, Mauro; Vitali, Silvia; Polito, Letizia; Abbondanza, Simona; Valle, Eleonora; Forloni, Gianluigi; Villani, Simona

doi:10.1016/j.archger.2014.11.006

Cited by 26 publications

(22 citation statements)

References 75 publications

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“…Individuals carrying the ε4 allele have an increased risk of developing AD [51]; in contrast, the ε2 allele is protective [52,53,54]. The same correlation exists for the pcb-Cohort.…”

Section: Discussionmentioning

confidence: 57%

Screening Younger Individuals in a Primary Care Setting Flags Putative Dementia Cases and Correlates Gastrointestinal Diseases with Poor Cognitive Performance

Rosa¹,

Henriques²,

Carvalho³

et al. 2016

Dement Geriatr Cogn Disord

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Background/Aims: Diagnosing dementia is challenging in many primary care settings, given the limited human resources and the lack of current diagnostic tools. With this in mind, a primary care-based cohort was established in the Aveiro district of Portugal. Methods: A total of 568 participants were evaluated using cognitive tests and APOE genotyping. Results: The findings revealed a dementia prevalence of 12%. A strong correlation between increasing Clinical Dementia Rating (CDR) scores and education was clearly evident. Other highly relevant risk factors were activities of daily living (ADL), instrumental ADL, aging, depression, gender, the APOE ε4 allele, and comorbidities (depression as well as gastrointestinal, osteoarticular, and neurodegenerative diseases). A hitherto unreported, significant correlation between gastrointestinal disease and high CDR score was clearly observable. Conclusions: This study shows the merit of carrying out a dementia screening on younger subjects. Significantly, 71 subjects in the age group of 50-65 years were flagged for follow-up studies; furthermore, these cases with a potentially early onset of dementia were identified in a primary care setting.

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“…Individuals carrying the ε4 allele have an increased risk of developing AD [51]; in contrast, the ε2 allele is protective [52,53,54]. The same correlation exists for the pcb-Cohort.…”

Section: Discussionmentioning

confidence: 57%

Screening Younger Individuals in a Primary Care Setting Flags Putative Dementia Cases and Correlates Gastrointestinal Diseases with Poor Cognitive Performance

Rosa¹,

Henriques²,

Carvalho³

et al. 2016

Dement Geriatr Cogn Disord

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“…In our study, we found a higher prevalence of VaD and a lower prevalence of AD. Evidence is supported by a very recent Italian study, InveCe.Ab study [ 33 ]. In fact, Guaita and colleagues have reported that the overall dementia prevalence was 3% (95% CI: 2.1–4.1% ).…”

Section: Discussionmentioning

confidence: 99%

Pain Assessment in Elderly with Behavioral and Psychological Symptoms of Dementia

Malara¹,

Biase²,

Bettarini³

et al. 2016

JAD

100

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Background:Pain is under-detected and undertreated in people with dementia. The present study investigates the prevalence of pain in people with dementia hospitalized in nursing homes that are members of National Association of Third Age Residences (ANASTE) Calabria, and evaluates the association among pain, mood, and behavioral and psychological symptoms of dementia (BPSD).Objective:The aim of this study is to define the prevalence of pain in people with dementia in long term care facilities using scales of self-reporting and observational tools and, particularly, to study the relationship between pain and BPSD.Methods:A prospective observational study was carried out on 233 patients. Pain assessment was performed using self-reporting tools such as the Numeric Rating Scale (NRS) for patients with slight cognitive impairment or no cognitive impairment and observational tools such as Pain Assessment In Advanced Dementia Scale (PAINAD) for patients with moderate or severe cognitive impairment. Mood was evaluated through the Cornell Scale for Depression in Dementia (CSDD) while behavioral problems were assessed through the Cohen-Mansfield Agitation Inventory (CMAI) and Neuropsychiatric Inventory (NPI).Results:Only 42.5% of patients evaluated by NRS provided a reliable answer; of these, 20.4% reported no pain. The percentage of pain evaluated by PAINAD was 51.8% . Analysis of data showed a statistically significant correlation between diagnosis of pain and depressive symptoms, assessed with CSDD (p = 0.0113), as well as by single items of NPI, such as anxiety (p = 0.0362) and irritability (p = 0.0034), and F1 profile (Aggression) of CMAI (p = 0.01).Conclusion:This study confirms that self-report alone is not sufficient to assess pain in elderly people with dementia; the observational tool is a necessary and suitable way of assessing pain in patients with cognitive impairment. If not adequately treated, chronic pain can cause depression, agitation, and aggression in patients with dementia.

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“…InveCe.Ab had a response rate of 80.4%, and no differences in age, birth area, or level of education were found between the responders and the nonresponders [15]. For the purposes of the present study, we excluded individuals who refused medical or neuropsychological assessment and therefore had no definitive diagnosis ( n = 15) and those with a diagnosis of dementia ( n = 39), psychosis ( n = 11), or mental retardation ( n = 2).…”

Section: Methodsmentioning

confidence: 99%

Subthreshold Depression and Clinically Significant Depression in an Italian Population of 70–74-Year-Olds: Prevalence and Association with Perceptions of Self

Vaccaro

Borrelli

Abbondanza

et al. 2017

BioMed Research International

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Estimates of depressive disorders in the elderly vary depending on how cases are defined. We estimated the prevalence of subthreshold depression (SD) and clinically significant depression (D) in a population of 70–74-year-olds. We also looked for associations with sociodemographic factors and perceptions of self. Participants underwent a multidimensional assessment (social, medical, and neuropsychological). The estimated prevalence of SD was 15.71% (95% CI: 13.70–17.72), while that of D was 5.58% (95% CI: 4.31–6.85). Multinomial logistic regression analysis revealed that female gender and dissatisfaction with family relationships were related to SD and D. A self-perception of physical age as older than actual age (but not comorbidity) and greater self-perceived stress caused by negative life events both increased the probability of SD. The likelihood of D was decreased in those who perceived their own health as good, whereas a self-perception of mental age as older than actual age and dissatisfaction with relationships with friends were both significantly associated with D. Both SD and D emerged as key problems in our population. Female gender and self-perceptions of various characteristics, which can be explored through simple questions, are associated with late-life depression in elderly people independently of their actual physical condition and other characteristics.

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Influence of socio-demographic features and apolipoprotein E epsilon 4 expression on the prevalence of dementia and cognitive impairment in a population of 70–74-year olds: The InveCe.Ab study

Cited by 26 publications

References 75 publications

Screening Younger Individuals in a Primary Care Setting Flags Putative Dementia Cases and Correlates Gastrointestinal Diseases with Poor Cognitive Performance

Screening Younger Individuals in a Primary Care Setting Flags Putative Dementia Cases and Correlates Gastrointestinal Diseases with Poor Cognitive Performance

Pain Assessment in Elderly with Behavioral and Psychological Symptoms of Dementia

Subthreshold Depression and Clinically Significant Depression in an Italian Population of 70–74-Year-Olds: Prevalence and Association with Perceptions of Self

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