Influence of socio-economic status and educational achievement on cataract formation in a rural community in Imo State, South-Eastern Nigeria

Rolnick, Kevin; Buck, Sean; Mezu-Nnabue, Kelechi; Eickhoff, Jens; Esenwah, E.C.; Mezu‐Ndubuisi, Olachi J.

doi:10.1080/2331205x.2017.1326212

Cited by 1 publication

(1 citation statement)

References 21 publications

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“…Epidemiological risk factors for cataracts include age [ 61 ], sex [ 34 , 62 , 63 ], living in a low-resourced area [ 56 , 57 , 61 , 64 ], educational status [ 65 ], smoking [ 66 , 67 ], diabetes [ 50 , 68 ], and environmental factors [ 69 ]. Cataracts may appear in the eye when a patient is in their 40s or 50s, although may not start to impact their vision until they are in their 60s [ 58 ].…”

Section: Introductionmentioning

confidence: 99%

Pseudoexfoliation and Cataract Syndrome Associated with Genetic and Epidemiological Factors in a Mayan Cohort of Guatemala

Hicks

Self

et al. 2021

IJERPH

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The Mayan population of Guatemala is understudied within eye and vision research. Studying an observational homogenous, geographically isolated population of individuals seeking eye care may identify unique clinical, demographic, environmental and genetic risk factors for blinding eye disease that can inform targeted and effective screening strategies to achieve better and improved health care distribution. This study served to: (a) identify the ocular health needs within this population; and (b) identify any possible modifiable risk factors contributing to disease pathophysiology within this population. We conducted a cross-sectional study with 126 participants. Each participant completed a comprehensive eye examination, provided a blood sample for genetic analysis, and received a structured core baseline interview for a standardized epidemiological questionnaire at the Salama Lions Club Eye Hospital in Salama, Guatemala. Interpreters were available for translation to the patients’ native dialect, to assist participants during their visit. We performed a genome-wide association study for ocular disease association on the blood samples using Illumina’s HumanOmni2.5-8 chip to examine single nucleotide polymorphism SNPs in this population. After implementing quality control measures, we performed adjusted logistic regression analysis to determine which genetic and epidemiological factors were associated with eye disease. We found that the most prevalent eye conditions were cataracts (54.8%) followed by pseudoexfoliation syndrome (PXF) (24.6%). The population with both conditions was 22.2%. In our epidemiological analysis, we found that eye disease was significantly associated with advanced age. Cataracts were significantly more common among those living in the 10 districts with the least resources. Furthermore, having cataracts was associated with a greater likelihood of PXF after adjusting for both age and sex. In our genetic analysis, the SNP most nominally significantly associated with PXF lay within the gene KSR2 (p < 1 × 10−5). Several SNPs were associated with cataracts at genome-wide significance after adjusting for covariates (p < 5 × 10−8). About seventy five percent of the 33 cataract-associated SNPs lie within 13 genes, with the majority of genes having only one significant SNP (5 × 10−8). Using bioinformatic tools including PhenGenI, the Ensembl genome browser and literature review, these SNPs and genes have not previously been associated with PXF or cataracts, separately or in combination. This study can aid in understanding the prevalence of eye conditions in this population to better help inform public health planning and the delivery of quality, accessible, and relevant health and preventative care within Salama, Guatemala.

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