Influence of sodium formate in γ-glycine single crystals – Synthesis, growth and characterization

Ethanol-free antisolvent crystallization of glycine by liquefied dimethyl ether

“…The additional liquefied DME made the glycine particles smaller overall. However, in the XRD pattern shown in Figure 4 (e), not only was α-glycine observed, but γ-glycine, the stable phase [ 33 , 34 , 35 , 36 ], was also detected. When the amount of additional liquefied DME was increased to 222 mL, the crystal structure of glycine changed to become cube-like ( Figure 3 (f)) and the XRD pattern showed only γ-glycine ( Figure 4 (f)).…”

“…The crystal structure of the glycine powder was analyzed by powder XRD. As a pretreatment for XRD analysis, the glycine powder was completely dried by sealing it in a desiccator for 1 day at a relative humidity of 20 % and 20-25 C. The XRD patterns of the powders treated and not treated with additional liquified DME both showed peaks corresponding to good crystallinity of α-glycine (Figure 4(a-c)) [33,34,35,36]. The formation of the metastable α-glycine suggests that the solubility of glycine decreased very rapidly due to the swift dissolution of water from the glycine solution into the liquefied DME.…”