Geocells are increasingly used in engineering applications, but the design of riverbank slope reinforcements that use only geocells limits reinforcement performance. Moreover, the design and use of anti-slide piles with geocells are mainly based on experiences that are unsupported by theoretical models. In this paper, by combining the confinement effect and vertical action mechanism of geocells, the horizontal friction mechanism of the geocell layer and the vertical support mechanism of piles, a theoretical model of riverbank slope reinforced by anti-slide piles with geocells was constructed. In addition, to describe the mechanical behavior of a riverbank slope reinforced by anti-slide piles with geocells, the slip-resisting mechanism of the anti-slide pile with interaction between geocells and their internal filler is considered in the model. Furthermore, to investigate the influence of changes in water level on riverbank slope stability, the developed model takes into account settlement, lateral displacement, pile bending moment and pile axial force. The model predications were validated by the field measurement data. The results from a series of parametric studies show that the use of anti-slide pile and geocells can effectively reduce the settlement and the lateral displacement of a riverbank slope. The developed model could contribute to an optimal design of anti-slide pile with geocells for enhancing the stability of a riverbank slope.