Influence of solution chemistry on the solubility, crystallisability and nucleation behaviour of eicosane in toluene : acetone mixed-solvents

Kaskiewicz, Peter L.; Rosbottom, Ian; Corzo, Diana M. Camacho; Hammond, R. B.; Downie, Ruth; Dowding, P.; George, Neil

doi:10.1039/d1ce00322d

Cited by 11 publications

(17 citation statements)

References 44 publications

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“…This suggests that homogeneous interactions, either between solute− solute or solvent−solvent, are preferred, rather than heterogeneous interactions between solvent and solute in solution. 64 The increase in ethanol concentration resulted in a greater deviation from the ideal behavior for all compounds. The highest change in activity coefficient between the two solvents was observed with D-xylose, which has also the lowest ΔH diss , indicating its higher solubility compared to the other solid forms.…”

Section: ■ Results and Discussionmentioning

confidence: 97%

“…This suggests that homogeneous interactions, either between solute–solute or solvent–solvent, are preferred, rather than heterogeneous interactions between solvent and solute in solution. 64 …”

Section: Resultsmentioning

confidence: 99%

“…For all species, the ideal solubilities are higher than the experimental ones, in both solvents and within the temperature range analyzed. This suggests that homogeneous interactions, either between solute–solute or solvent–solvent, are preferred, rather than heterogeneous interactions between solvent and solute in solution …”

Section: Resultsmentioning

confidence: 99%

“…Equation 4 was used to interpolate the experimental values, where Δ H diss and Δ S diss are the enthalpy and entropy of dissolution of the solid in the solvent studied. 64 The experimental solubilities and the thermodynamic parameters extrapolated were compared with the ideal values estimated from thermal data ( eq 2 ).…”

Section: Methodsmentioning

confidence: 99%

“…Equation 4 was used to interpolate the experimental values, where ΔH diss and ΔS diss are the enthalpy and entropy of dissolution of the solid in the solvent studied. 64 x H RT S R ln( )…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Crystallization Behavior and Crystallographic Properties ofdl-Arabinose anddl-Xylose Diastereomer Sugars

Tyson

Pask

George

et al. 2022

Crystal Growth & Design

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Natural sugar molecules such as xylose and arabinose exhibit sweetness profiles similar to sucrose, which makes them a valuable alternative in low-calorie foods as well as excipients or cocrystallization agents in pharmaceutical formulations. Xylose and arabinose are also chiral diastereomers that can exhibit specific crystallization behavior. In this work, the solid-state landscapes of the chiral pairs of both xylose and arabinose have been investigated to determine whether racemic compounds or conglomerates are formed. Furthermore, single crystals of xylose and arabinose have been grown and characterized by X-ray diffraction and optical microscopy to study their crystallographic properties and relate them to the crystallization behavior. Differential scanning calorimetry (DSC) measurements were used to determine the phase diagrams of the two analyzed chiral systems. The solubilities of the different solid forms of xylose and arabinose were measured in different solvent mixtures by a thermogravimetric method. An analysis was conducted to assess the main thermodynamic parameters and the activity coefficients of the compounds in solution. Finally, slurry experiments in a 50:50 w/w ethanol/water solvent have also been performed to determine the relative stability of each solid form and the kinetics of transformation in this solvent mixture. It was found that dl -arabinose crystallizes as a stable racemic compound, which transforms quickly from its constituent enantiomers when in solution; whereas d - and l -xylose molecules crystallize separately as a conglomerate.

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Section: ■ Results and Discussionmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%