Influence of Some<i>Stachys</i>. Taxa on Carrageenan-Induced Paw Edema in Rats

Kukić, Jelena; Dobrić, Silva; Petrović, Silvana

doi:10.1080/13880200701498937

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…The antiinflammatory activities of the hydroalcohol, acetone and ethyl acetate extracts of several Stachys species ( S. inflata , S. chrysantha, S. candida, S. athorecalix, S. beckeana, S. anisochila, S. plumosa and S. alpina subsp. dinarica ) have been established in in vivo animal models (Maleki et al ., ; Skaltsa et al ., ; Rezazadeh et al ., ; Kukic et al ., ). Previous investigations revealed that the main iridoid components of Stachys species, such as aucubin, harpagide and harpagoside, exert antiinflammatory activities, as demonstrated in cellular systems of arachidonic acid metabolism (Benito et al ., ; Gyurkovska et al ., ), by the inhibition of tumour necrosis factor‐α production(Park and Chang, ) and in in vivo experiments on mice (Kupeli et al ., ; Villasenor, ).…”

Section: Introductionmentioning

confidence: 97%

Antiinflammatory Activities of Hungarian Stachys species and Their Iridoids

Háznagy-Radnai

Balogh

Czigle

et al. 2011

Phytotherapy Research

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The antiinflammatory activities of aqueous extracts prepared from the aerial parts of ten Hungarian Stachys species were investigated in vivo in the carrageenan-induced paw oedema test after intraperitoneal and oral administration to rats. Some of the extracts were found to display significant antiphlogistic effects when administered intraperitoneally and orally; in particular, the extracts of S. alpina, S. germanica, S. officinalis and S. recta demonstrated high activity following intraperitoneal administration. At the same dose of 5.0 mg/kg, these extracts exhibited similar or greater potency than that of the positive control diclofenac-Na. The main iridoids present in the investigated extracts, ajugoside, aucubin, acetylharpagide, harpagide and harpagoside, were also assayed in the same test, and high dose-dependent antiphlogistic effects were recorded for aucubin and harpagoside. These results led to the conclusion that most probably iridoids are responsible for the antiinflammatory effect of Stachys species, but other active constituents or their synergism must also be implicated in the antiinflammatory effect.

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Section: Introductionmentioning

confidence: 97%

Antiinflammatory Activities of Hungarian Stachys species and Their Iridoids

Háznagy-Radnai

Balogh

Czigle

et al. 2011

Phytotherapy Research

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“…Studies in the Stachys species showed the presence of polyphenols including tannins (Vundac et al 2007), flavonoids (El-Ansari et al 1995), and phenolic acids (Vundac et al 2005). Many researches detected various activities in this genus such as antibacterial (Grujic-Jovanovic et al 2004;Sonboli et al 2005;Slobodianiuk et al 2021d), anti-inflammatory (Khanavi et al 2005;Sharifzadeh et al 2005;Kukik et al 2007), and antioxidant effects (Aydin et al 2006;Matkowski and Piotrowska 2006).…”

Section: Introductionmentioning

confidence: 99%

Investigation of amino acids content in the herb and tubers of Stachys sieboldii

Marchyshyn¹,

Mysula²,

Kishchuk³

et al. 2022

PHAR

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The aim of this research was the comparative study of the content of the amino acids in the herb and tubers of Stachys sieboldii. The study of the amino acid composition of the raw materials was carried out using high-performance liquid chromatography (HPLC). The results obtained have shown that the aerial parts of plants investigated have higher amino acid content than the underground organs. Free and bound L-aspartic acid, L-proline, and L-phenylalanine were present in the analyzed samples in the greatest amount. Moreover, L-cysteine was found only in Stachys sieboldii tubers in amounts (8.11 mg/g). This research established that Stachys sieboldii herb and tubers have the most suitable amino acids composition and are prospective for further pharmacological studies.

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“…The genus Stachys L. (Lamiaceae) comprises about 300 species widespread throughout the world. Some of them were traditionally recognized as astringent, wound-healing, antidiarrhoeal, antinephritic and anti-infl ammatory agents (Hayashi et al, 1996;Maleki et al, 2001;Khanavi et al, 2005;Kukić et al, 2007). Additionally, the use of some Stachys species as psychotropic remedies is well documented.…”

Section: Introductionmentioning

confidence: 99%

“…Caffeoyl glycosides verbascoside, martinoside, and forsythoside B, as well as monoacetyl derivative of isoscutellarein 7-O-β-D-allopyranosyl-(1→2)-β-D-glucopyranoside were detected in S. plumosa (Bankova et al, 1999). It was shown that the crude methanol extracts of aerial parts of these four Stachys taxa possess substantial antioxidant and free radical scavenging activity (Kukić et al, 2006a) and exhibit anti-infl ammatory effects (Kukić et al, 2007). According to our fi eld observations, S. alpina subsp.…”

Section: Introductionmentioning

confidence: 99%

Behavioural characterization of four endemic Stachys taxa

Savić¹,

Kukić²,

Grayer³

et al. 2010

Phytotherapy Research

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We performed a basic behavioral characterization of methanol extracts of four Balkan endemic Stachys taxa: S. anisochila (SA), S. beckeana (SB), S. plumosa (SP) and S. alpina subsp. dinarica (SAD). The behavioral activity of extracts dosed intraperitoneally in the range 100-400 mg/kg was examined in adult male Wistar rats, in the elevated plus maze, spontaneous locomotor activity, and grip strength tests, mainly predictive of anxiolytic, sedative and myorelaxant actions, respectively. All investigated Stachys extracts lacked anxiolytic or myorelaxant activities, while SB at 400 mg/kg exerted an anxiogenic-like effect. The study with the selective antagonist beta-CCt showed that the sedative effect of SAD was only partially mediated by GABAA receptors containing the alpha1-subunit. While discernible, the behavioral effects of SA and SP were not distinct. In all extracts, chlorogenic acid and verbascoside were identified. In SA, SB, and SAD the flavonoid fraction was constituted of isoscutellarein and hypolaetine glycosides, while in SP chrysoeriol and apigenin glycosides were present. The results reveal the psychotropic potential of four endemic Stachys taxa, of which SAD appeared most promising as a natural sedative.

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Influence of SomeStachys. Taxa on Carrageenan-Induced Paw Edema in Rats

Cited by 7 publications

References 28 publications

Antiinflammatory Activities of Hungarian Stachys species and Their Iridoids

Antiinflammatory Activities of Hungarian Stachys species and Their Iridoids

Investigation of amino acids content in the herb and tubers of Stachys sieboldii

Behavioural characterization of four endemic Stachys taxa

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