Influence of some Trace Elements and Biochemical Parameters on Breast Cancer

Mahmood, Ameera Aziz; Bilal, Kinda Masood; Ibrahim, Rana T.

doi:10.33899/edusj.2012.58994

Cited by 4 publications

(3 citation statements)

References 34 publications

(46 reference statements)

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“…This study agrees with Seema and his group (22) and Fagherazzi et al (23), where a significant decrease in the level of total cholesterol was observed in breast cancer patients compared to the control group due to its increased use by tumor cells to build a new biofilm. The present results do not agree with Al-Faraji ( 24), Mahmoud et al (25), Al-Rabee et al (26), Wehbe et al (27), and Alacacioglu et al (28), where a significant increase was observed in the level of cholesterol in women with breast cancer and this it may be due to metabolism and increased fat oxidation, which may be associated with cancers because it has an important role in maintaining cell integrity. The cholesterol formation pathway may also produce different tumor compounds.…”

Section: Resultscontrasting

confidence: 87%

Evaluation of interleukin-7 and lipid profile in breast cancer women

Abbas¹,

Alsamarai

2022

ijhs

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Breast cancer is one of the most common cancerous tumors and one of the main causes after lung cancer that leads to death, and the most common type of breast cancer is adenocarcinoma and is usually detected either during the examination before symptoms appear or after the woman notices the presence of the tumor. Breast cancer is one of the most common diseases in Iraq recently. This study was designed to measure the level of interleukin-7 and its role in cancer, as well as to find out the Level of lipids (cholesterol, triglycerides, and high-density lipoproteins) in breast cancer women and compare them with the control group. The results showed a significant increase( P≤ 0.05) in the level of interleukin-7and high-density lipoprotein cholesterol (357.505±89.921µg\L, 104.383±20.865mg\dl) respectively among patients with breast cancer compared with the control group (150.705±39.559µg\L,114.782±14.139mg\dl) respectively, , and the results showed a significant decrease ( P≤ 0.05) in the level of cholesterol a and triglycerides in patients with breast cancer (104.383±20.865mg\dl , 110.388±18.180mg\dl) respectively compared with the control group(114.782±14.139mg\dl, 138.925±23.178mg\dl) respectively.

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Section: Resultscontrasting

confidence: 87%

Evaluation of interleukin-7 and lipid profile in breast cancer women

Abbas¹,

Alsamarai

2022

ijhs

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“…In addition, it is considered as measure of the susceptibility or progression of a range of neurological, developmental and metabolic disorders, including diabetes and cardiovascular disease, it also linked to CD . The value of Cu/Zn mean ratio observed in our study was increased for the global population in the plasma of cancer patients compared to healthy control according to Mahmood et al…”

Section: Resultssupporting

confidence: 63%

Determination of trace elements Fe, cu and Zn in the Algerian cancerous plasma using X‐ray fluorescence (XRF)

et al. 2019

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Cancers are among the leading causes of morbidity and mortality in the world.The purpose of this study was to conduct a survey on the effect of minerals on cancer risk in the Algerian population. One hundred and seventy-eight plasma samples were used to analyze the concentrations of iron (Fe), copper (Cu), and zinc (Zn) in cancerous patients and also in healthy subjects using the X-ray florescence technique (XRF). Samples were classified according to the age and gender of the donors. An empirical formula was developed for the concentration of Zinc, Copper and Iron in cancer patients according to the age. The averages iron, copper and zinc concentrations in mg/kg for control and Cancer disease groups were (1493 ± 105; 1496 ± 86), (1172 ± 229; 1078 ± 283) and (1266 ± 202; 1344 ± 208) respectively. The ANOVA One-Way test was applied. For both genders of control and cancer disease groups it shows a significant decrease rate of copper for global and female gender and a significant increase rate of zinc for global and male gender (p < 0.05). The results indicate that the Cu and Zn concentration could show helpful tools for diagnosis and preventive treatment of cancer diseases.

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“…Similar to our findings, in study carried by Mahmood AA, et al, the women with breast cancer exhibited a significant increase in the level of serum Cu as compared to the controls (P < 0.009). On the other hand, serum Zn level was significantly lower in the breast cancer group (P < 0.002) than in the control [21].…”

Section: Discussionmentioning

confidence: 73%

The Role of Serum Trace Elements and Oxidative Stress in Egyptian Breast Cancer Patients

Eldeeb¹,

El-Sheredy²,

Mohammed³

2016

ABCR

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Background: Oxidative stress is considered to be involved in the pathophysiology of all cancers. Studies indicated that the levels of oxidative stress markers increased in breast cancer. Trace metals are essential to normal human homeostasis. When present in an abnormal expression, they contribute in many pathological processes. Some trace metals are claimed to be carcinogenic and capable of inducing a toxic effect through the formation of free radicles and acting as cofactors in the oxidative damage of biological macromolecules and DNA. Objective: Our aim was to investigate the serum levels of some trace elements (Copper, Zinc and Cadmium), the total oxidative and antioxidative capacity (TOC and TAC) in patients with breast cancer in comparison to patients with benign breast tumours. Patients and Methods: The present study included 65 females. The participates were divided into 2 main groups: control group which consisted of 20 apparently healthy female; the patient groups which divided into 3 groups: group B included 15 patients with benign breast tumours, group N consisted of 15 newly diagnosed breast cancer patients and group M included 15 patients with metastatic breast cancer. Results: The mean serum levels of Copper, Zinc, and Cadmium were significantly higher in the three patients groups (B, N and M) than the control group. Similarly, serum uric acid (UA) and (TAC) levels showed significant higher level in both breast cancer groups as compared to the benign group. However TOC levels showed only significantly higher level in metastatic group. Conclusions: The present study suggested elevated TAC, UA and TOC in breast cancer patients. The increased levels of trace elements could lead to formation of free radicals or other reactive oxygen species. The serum profile of these trace metals may be helpful in predicting prognosis of breast cancer.

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Influence of some Trace Elements and Biochemical Parameters on Breast Cancer

Cited by 4 publications

References 34 publications

Evaluation of interleukin-7 and lipid profile in breast cancer women

Evaluation of interleukin-7 and lipid profile in breast cancer women

Determination of trace elements Fe, cu and Zn in the Algerian cancerous plasma using X‐ray fluorescence (XRF)

The Role of Serum Trace Elements and Oxidative Stress in Egyptian Breast Cancer Patients

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