Influence of Some Uremic Toxins on Oxygen Consumption of Rats in Vivo and in Vitro

Hohenegger, M; Echsel, H.; Vermes, M.; Raneburger, H.

doi:10.1007/978-1-4684-8240-9_13

Cited by 3 publications

(8 citation statements)

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“…A previous study reported that the accumulation of IS and a neurotransmitter metabolite in the brain caused CNS dysfunction in rats with CRF (31). In addition, it was reported that increases in uremic toxins cause hypothermia (32). Hence, the present results indicate that an increased IS level in the brain might disrupt thermoregulatory mechanisms and induce a decreased rectal temperature.…”

Section: Discussionmentioning

confidence: 76%

Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-induced Acute Renal Failure

et al. 2007

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Section: Discussionmentioning

confidence: 76%

Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-induced Acute Renal Failure

et al. 2007

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“…[3][4][5][6][7] Small molecules that are removed easily by dialysis may be involved in the pathogenesis of UH given our findings. Disproportionate changes in concentrations of various solutes may also affect temperature regulation because neither middle molecules (eg, cytokines, b2 microglobulin, cyanocobalamin) nor large molecules (most hormones) are effectively removed by the hemophane dialyzers used in approximately 1/3 of the dialysis treatments in this study.…”

Section: Part 2: Intermittent Hemodialysis In Uremic Patientsmentioning

confidence: 52%

“…Hypometabolism at the cellular level secondary to the effects of uremic toxins is one of the main proposed mechanisms. [3][4][5][6] Uremic hypothermia also is addressed in the veterinary literature, albeit less directly. A retrospective study evaluating rectal temperatures of male cats with urethral obstruction found that BUN and serum creatinine concentrations were significantly higher in the hypothermic group.…”

Section: Discussionmentioning

confidence: 99%

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Hypothermia in uremic dogs and cats

2017

Advances in Small Animal Medicine and Surgery

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Background: The prevalence of uremic hypothermia (UH) and the effects of improving uremia on body temperature have not been determined in veterinary patients.Objectives: To determine the prevalence of UH and correlations between uremia and body temperature in patients undergoing intermittent hemodialysis (IHD).Animals: Uremic dogs (n = 122) and cats (n = 79) treated by IHD at the Bobst Hospital of the Animal Medical Center from 1997 to 2013.Methods: Retrospective review of medical records.Results: The prevalence of hypothermia was 38% in azotemic cats and 20.5% in azotemic dogs. Statistically significant temperature differences were observed between uremic and nonuremic dogs (nonuremic: mean, 100.8°F; range, 91.2-109.5°F; uremic: mean, 99.9°F; range, 95.6-103.8°F; P < .0001) and cats (nonuremic: mean, 100.6°F; range, 94.0-103.8°F; uremic: mean, 99.3°F; range, 92.3-103.4°F; P < .0001). In dog dialysis patients, significant models included (1) timing (pre-dialysis versus post-dialysis) with weight class (small [P < .0001], medium [P = .016], and large breed [P = .033] dogs), (2) timing with serum creatinine concentration (P = .021), and (3) timing with BUN concentration (P < .0001). In cat dialysis patients, there was a significant interaction between timing and weight as a categorical variable (<5 kg and ≥5 kg).Conclusions and Clinical Importance: Uremic hypothermia appears to be a clinical phenomenon that occurs in cats and dogs. Uremic patients are hypothermic compared to ill nonuremic patients and body temperatures increase when uremia is corrected with IHD in dogs and in cats >5 kg. In cats, UH seems to be a more prevalent phenomenon driven by uremia. Uremic hypothermia does occur in dogs, but body weight is a more important predictor of body temperature.

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“…Later, a 1987 study hypothesized that UH is secondary to a reduction in metabolic rate and concluded that the direct action of toxic substances at the cellular level was the cause. This study was unable to show the effect of specific toxins . A 1981 study investigating endogenous cryogens excreted by the kidneys concluded that dialysis of urinary cryogens led to increased body temperature .…”

mentioning

confidence: 93%

Hypothermia in Uremic Dogs and Cats

Kabatchnick

Langston

Olson

et al. 2016

Veterinary Internal Medicne

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BackgroundThe prevalence of uremic hypothermia (UH) and the effects of improving uremia on body temperature have not been determined in veterinary patients.ObjectivesTo determine the prevalence of UH and correlations between uremia and body temperature in patients undergoing intermittent hemodialysis (IHD).AnimalsUremic dogs (n = 122) and cats (n = 79) treated by IHD at the Bobst Hospital of the Animal Medical Center from 1997 to 2013.MethodsRetrospective review of medical records.ResultsThe prevalence of hypothermia was 38% in azotemic cats and 20.5% in azotemic dogs. Statistically significant temperature differences were observed between uremic and nonuremic dogs (nonuremic: mean, 100.8°F; range, 91.2–109.5°F; uremic: mean, 99.9°F; range, 95.6–103.8°F; P < .0001) and cats (nonuremic: mean, 100.6°F; range, 94.0–103.8°F; uremic: mean, 99.3°F; range, 92.3–103.4°F; P < .0001). In dog dialysis patients, significant models included (1) timing (pre‐dialysis versus post‐dialysis) with weight class (small [P < .0001], medium [P = .016], and large breed [P = .033] dogs), (2) timing with serum creatinine concentration (P = .021), and (3) timing with BUN concentration (P < .0001). In cat dialysis patients, there was a significant interaction between timing and weight as a categorical variable (<5 kg and ≥5 kg).Conclusions and Clinical ImportanceUremic hypothermia appears to be a clinical phenomenon that occurs in cats and dogs. Uremic patients are hypothermic compared to ill nonuremic patients and body temperatures increase when uremia is corrected with IHD in dogs and in cats >5 kg. In cats, UH seems to be a more prevalent phenomenon driven by uremia. Uremic hypothermia does occur in dogs, but body weight is a more important predictor of body temperature.

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Influence of Some Uremic Toxins on Oxygen Consumption of Rats in Vivo and in Vitro

Cited by 3 publications

References 5 publications

Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-induced Acute Renal Failure

Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-induced Acute Renal Failure

Hypothermia in uremic dogs and cats

Hypothermia in Uremic Dogs and Cats

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