Two different stress raiser geometries (fillets and notched) were treated by laser shock peening (LSP) in order to analyze the effect of sample geometry on fatigue behavior of 2205 duplex stainless steel (DSS). The LSP treatment was carried through Nd : YAG pulsed laser with 1064 nm wavelength, 10 Hz frequency, and 0.85 J/pulse. Experimental and MEF simulation results of residual stress distribution after LSP were assessed by hole drilling method and ABAQUS/EXPLICIT software, respectively. The fatigue tests (tensile-tensile axial stress) were realized with stress ratio of R = 0.1 and 20 Hz. A good comparison of residual stress simulation and experimental data was observed. The results reveal that the fatigue life is increased by LSP treatment in the notched samples, while it decreases in the fillet samples. This is related to the residual stress distribution after LSP that is generated in each geometry type. In addition, the fatigue crack growth direction is changed according to geometry type. Both the propagation direction of fatigue crack and the anisotropy of this steel results detrimental in fillet samples, decreasing the number of cycles to the fatigue crack initiation. It is demonstrated that the LSP effect on fatigue performance is influenced by the specimen geometry.