Influence of Statins on LDL- and HDL-Cholesterol and Plasma Fatty Acids in Elderly Japanese Ischemic Stroke Patients

Mori, Takahisa

doi:10.26420/austinjcerebrovascdisstroke.2017.1062

Cited by 1 publication

(1 citation statement)

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“…Stepwise linear regression analysis to find independent determinants of TG showed that the adjusted R2 was 0.72 and that OlA (18:1 n-9 MUFA), AlA (20:4 n-6 PUFA) and PA% were positive determinants (Table 4- Statins are commonly used to treat hypercholesterolemia and they can reduce serum T-CHO and LDL-C levels [15]. However, a previous study reported that stains were not able to change s-FA levels [16].…”

Section: Resultsmentioning

confidence: 99%

Associations of Serum Fatty Acids with Serum Lipids Parameters in Ischaemic Stroke Patients

Mori

Yoshioka

2019

Preprint

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Background: Serum fatty acids (s-FA) are likely associated with serum lipids parameters (s-LP), such as total cholesterol (T-CHO), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and triglycerides (TG), because fatty acids (FA) are components of lipoproteins. However, little is known about the association of s-FA with s-LP. The aim of our retrospective study was to investigate the association of s-FA with s-LP in Ischaemic stroke patients. Methods: We conducted a cross-sectional study of ischaemic stroke patients aged 50 years or older who 1) were admitted to our institution between September 2015 and March 2017 within 24 hours of stroke onset and 2) took blood examination of s-FA levels of palmitic acid (PA), stearic acid (StA), oleic acid (OlA), linoleic acid (LiA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We evaluated correlation of serum levels or composition percentage (%) of FA with s-LP. Results: One hundred ninety-one patients met our inclusive criteria. Their average age was 74.4 years, BMI was 23.4 kg/m2, T-CHO was 203.4, LDL-C was 121.7, HDL-C was 58.5 and TG was 116.2 mg/dl. Stepwise linear regression analysis showed that LiA and AA were independent positive factors of T-CHO, AA and LiA% were independent positive factors of LDL-C, AA was an independent positive factor of HDL-C, AA% and LiA% were independent inverse factors of HDL-C, and OlA was an independent positive factor of TG. Conclusions: Serum FA had correlation with s-LP in ischaemic stroke patients. The results warrant clinical application of s-FA modification to improve s-LP.

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Section: Resultsmentioning

confidence: 99%