2005
DOI: 10.1007/s11745-005-1489-7
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Influence of stearic acid on postprandial lipemia and hemostatic function

Abstract: It has been suggested that fats rich in stearic acid may result in exaggerated postprandial lipemia and have adverse effects on hemostatic function. The effects of test meals containing different saturated and monounsaturated FA were compared in healthy subjects in a series of studies to investigate this hypothesis. Stearic acid, when present as cocoa butter, resulted in similar postprandial lipemia and factor VII activation compared with a meal containing high-oleic sunflower oil. Stearic acid when presented … Show more

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Cited by 19 publications
(13 citation statements)
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“…There is convincing evidence that meals high in fat (usually 50 g fat) compared to meals high in carbohydrate and low in fat ( ! 15 g fat) acutely increase the concentration of FVIIa [Oakley et al, 1998;Sanders et al, 1999Sanders et al, , 2000Sanders et al, , 2001Sanders et al, , 2003bSanders et al, , 2006bTholstrup et al, 2003;Sanders and Berry, 2005]. There is probable evidence that the increase in FVIIa is greater following meals rich in MUFA (oleic acid) than for some sources of SFA [Sanders et al, 2000[Sanders et al, , 2006bTholstrup et al, 2003;Sanders and Berry, 2005;Berry et al, 2007a, b].…”
Section: Procoagulant and Fibrinolytic Activitymentioning
confidence: 99%
See 1 more Smart Citation
“…There is convincing evidence that meals high in fat (usually 50 g fat) compared to meals high in carbohydrate and low in fat ( ! 15 g fat) acutely increase the concentration of FVIIa [Oakley et al, 1998;Sanders et al, 1999Sanders et al, , 2000Sanders et al, , 2001Sanders et al, , 2003bSanders et al, , 2006bTholstrup et al, 2003;Sanders and Berry, 2005]. There is probable evidence that the increase in FVIIa is greater following meals rich in MUFA (oleic acid) than for some sources of SFA [Sanders et al, 2000[Sanders et al, , 2006bTholstrup et al, 2003;Sanders and Berry, 2005;Berry et al, 2007a, b].…”
Section: Procoagulant and Fibrinolytic Activitymentioning
confidence: 99%
“…15 g fat) acutely increase the concentration of FVIIa [Oakley et al, 1998;Sanders et al, 1999Sanders et al, , 2000Sanders et al, , 2001Sanders et al, , 2003bSanders et al, , 2006bTholstrup et al, 2003;Sanders and Berry, 2005]. There is probable evidence that the increase in FVIIa is greater following meals rich in MUFA (oleic acid) than for some sources of SFA [Sanders et al, 2000[Sanders et al, , 2006bTholstrup et al, 2003;Sanders and Berry, 2005;Berry et al, 2007a, b]. There is insufficient evidence to demonstrate chronic effects of different types of fatty acids on fibrinogen or fibrinolytic activity [Miller, 2005;Sanders et al, 2006b], but fibrinolytic activity improves with intensive lifestyle intervention (weight reduction and increased physical activity) [Hamalainen et al, 2005].…”
Section: Procoagulant and Fibrinolytic Activitymentioning
confidence: 99%
“…Myristic and palmitic acids have the greatest LDL raising effect and are abundant in diets rich in dairy products and meat [7,8] . Stearic acid has not been reported to elevate blood cholesterol and has been shown to be rapidly converted to oleic acid in vivo, thus it is considered neutral in terms of the plasma cholesterol effect [35,36] ; less is known on other potential adverse effects of stearic acid on the CVD risk [37,38] . TFAs are similar to SFAs in their effect on LDL, but additionally they lower the protective HDL cholesterol and increase lipoprotein(a), which further increases the CHD risk.…”
Section: Fats Fatty Acids and Cholesterol And Risk Of Cardiovasculamentioning
confidence: 99%
“…This is a completely normal physiological response but an exaggerated postprandial lipaemia is known to be associated with an increased risk of developing CHD by a variety of mechanisms including the activation of factor VII and hence the blood coagulation cascade (13). Accord-…”
Section: Effects Of Trans Fatty Acids Stearic Acid and Palmitic Acidmentioning
confidence: 99%
“…On the basis of animal studies it was suggested that meals rich in stearic acid persist longer in the circulation and as a result provoke thrombosis (13). It is always unwise to extrapolate from the results of animal experiments to humans so a series of experiments on effects of meals rich in different fatty acids on postprandial lipaemia and factor VII activation was carried out.…”
Section: Effects Of Trans Fatty Acids Stearic Acid and Palmitic Acidmentioning
confidence: 99%