Influence of steric configurations in the conjugated polymers using acridine-triazine derivates as green chromophores

Fan, Zhijie; Sun, Jing; Yang, Xiaodong; Du, Jikuan; Miao, Yanqin; Dong, Hailiang; Wang, Hua

doi:10.1016/j.synthmet.2023.117531

Cited by 3 publications

(1 citation statement)

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“…Reactive groups, such as hydroxyl (-OH) and carboxyl (-COOH), of the extracts' phytochemicals can interact with polymeric chains, influencing spreadability. Steric interactions are also a possible mechanism through which spatial arrangements of phytocompounds' molecules can affect the conformation and flexibility of polymer chains [42,43]. Thus, the spreadability of the formulations is influenced by the extracts' composition, and the best results were recorded for Calendulae flos extract formulations.…”

Section: Discussionmentioning

confidence: 99%

Preparation and Preliminary Analysis of Several Nanoformulations Based on Plant Extracts and Biodegradable Polymers as a Possible Application for Chronic Venous Disease Therapy

Ungureanu,

Ozon,

Musuc

et al. 2024

Polymers

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Nanotechnology is one of the newest directions for plant-based therapies. Chronic venous disease often predisposes to long-term and invasive treatment. This research focused on the inclusion of vegetal extracts from Sophorae flos (SE), Calendulae flos (CE), and Ginkgo bilobae folium (GE) in formulations with PHB and PLGA polymers and their physicochemical characterization as a preliminary stage for possible use in the development of a complex therapeutic product. The samples were prepared by an oil–water emulsification and solvent evaporation technique, resulting in suspensions with high spreadability and a pH of 5.5. ATR-FTIR analysis revealed bands for stretching vibrations (O-H, C=O, and C-H in symmetric and asymmetric methyl and methylene) in the same regions as the base components, but switched to high or low wavenumbers and absorbance, highlighting the formation of adducts/complexes between the extracts and polymers. The obtained formulations were in the amorphous phase, as confirmed by XRD analysis. AFM analysis emphasized the morphological peculiarities of the extract–polymer nanoformulations. It could be noticed that, in the case of SE-based formulations, the dominant characteristics for SE-PHB and SE-PLGA composition were the formation of random large (SE-PHB) and smaller uniform (SE-PLGA) particles; further on, these particles tended to aggregate in the case of SE-PHB-PLGA. For the CE- and GE-based formulations, the dominant surface morphology was their porosity, generally with small pores, but larger cavities were observed in some cases (CE- and GE-PHB). The highest roughness values at the (8 µm × 8 μm) scale were found for the following samples and succession: CE-PHB < SE-PLGA < SE-PHB-PLGA. In addition, by thermogravimetric analysis, impregnation in the matrix of compression stockings was evaluated, which varied in the following order: CE-polymer > SE-polymer > GE-polymer. In conclusion, nine vegetal extract–polymer nanoformulations were prepared and preliminarily characterized (by advanced physicochemical methods) as a starting point for further optimization, stability studies, and possible use in complex pharmaceutical products.

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Section: Discussionmentioning

confidence: 99%