Influence of Steroidal Anti-Inflammatory Drugs on Viability and Fertility of Equine Semen

Abstract

a b s t r a c tConsidering the efficiency of steroidal anti-inflammatory drugs (SAIDs) in the immunomodulation of breeding-induced endometritis and the possibility of using these drugs by intrauterine route instead of the parenteral application, the present study aimed at evaluating the effect of SAIDs added to the semen extender on equine sperm viability and fertility. In experiment 1, 15 SAIDs were individually added to a skim milk-based extender and, based on the results of sperm motility, dexamethasone was the drug of choice for the subsequent trials. The effect of dexamethasone on the viability of fresh and 24-hour cooled semen was investigated in experiment 2. In experiment 3, fertility rate was measured in both post-breeding endometritis-resistant and susceptible mares. Although dexamethasone supplementation caused a premature decrease in sperm total and progressive motility and in sperm velocities (P < .05), no difference was observed for sperm membrane integrities and fertility (P > .05). Based on these results, we can conclude that dexamethasone can be added to equine semen at the time of insemination or before cooling, although its use was not able to increase fertility.

Glucocorticoid exposure modifies the miRNA profile of sperm in the guinea pig: Implications for intergenerational transmission

“…8 Patients receiving sGCs experience acute relief; however, chronic exposure has been shown to increase susceptibility to diabetes, hypertension, adrenal insufficiency, and various neuropsychiatric diseases. 3,5,6 Furthermore, long-term exposure to sGCs has been shown to negatively impact male fertility by impairing sperm quality, 9,10 inducing germ cell apoptosis, 11 and altering androgen production and spermatogenesis, 12 which may have implications for intergenerational transmission.…”