Influence of storage condition on properties of MCC II-based pellets with theophylline-monohydrate

Krueger, Cornelia; Thommes, Markus; Kleinebudde, Peter

doi:10.1016/j.ejpb.2014.06.006

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…The presence of lactose, which is brittle in nature, has resulted in crack to pellets’ surface under the applied stress with the exception of pellets that consist of 80% aid. Kruger et al . has showed that as lactose content (50–90%) in MCCII pellets increases, the pellets’ tensile strength values decrease supporting our observations for pellets produced in the similar range.…”

Section: Resultssupporting

confidence: 90%

“…Also, MCC powders originated from different suppliers were found to alter physicochemical properties of pellets . Thus, researchers have evaluated alternative spheronization aids such as k‐carrageenan, powdered cellulose, blend of starch plus dextrin, and even use of new grades of MCC, which is known as MCCII with the intention to overcome some of the limitations of standard MCC . Also, some researchers suggested mixing MCC and other excipients.…”

Section: Introductionmentioning

confidence: 99%

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Silicified microcrystalline cellulose based pellets and their physicochemical properties

Mustafa

Chaw

2016

J of Applied Polymer Sci

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Silicified microcrystalline cellulose (SMCC), Prosolv® SMCC 50 was used as spheronization aid to manufacture pellets by extrusion and spheronization. Different ratios of SMCC to lactose were used to manufacture pellets using appropriate levels of water as liquid binder. Avicel PH101 based pellets were also manufactured for comparison of their physical properties. The ratio of liquid binder to spheronization aid was critical to produce pellets of desired size and shape. Extrudates composed of 20% aid could withstand only smaller spheronization force in order to be shaped into pellets. The successful products fulfilled the quality of pellets such as narrow size distribution and spherical in shape. The highest surface tensile strength was observed in pellets with equal ratio of lactose to SMCC while pellets having 20% aid disintegrated rapidly within 15 minutes. Furthermore, Prosolv® SMCC 50 based pellets possessed a stronger surface tensile strength when compared with Avicel PH101 based pellets. In conclusion, Prosolv® SMCC 50 has showed to be a good spheronization aid for extrusion and spheronization when used in the range of 20 to 80% content.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Silicified microcrystalline cellulose based pellets and their physicochemical properties

Mustafa

Chaw

2016

J of Applied Polymer Sci

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“…The evaluation of the release curves was performed according to different models of release kinetics used by several authors [41][42][43][44]. In the first step of release evaluation, the amount of a cumulatively released substance is plotted compared to time.…”

Section: Linearization Of Release Curvesmentioning

confidence: 99%

Comparison of Mini-Tablets and Pellets as Multiparticulate Drug Delivery Systems for Controlled Drug Release

Priese,

Wiegel,

Funaro

et al. 2023

Coatings

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Mini-tablets made into hard capsules or administered using special dosing units, as well as pellets in hard capsules or compressed into tablets, offer the advantages of multiparticulate drug delivery systems and are suitable for controlled drug release using polymer coatings. Four different kinds of solid drug preparations were manufactured and investigated concerning drug release. Inert pellets were coated with the model drug sodium benzoate and, in a second step, with the insoluble polymer ethylcellulose. The coated pellets were compressed into mini-tablets and into normal tablets. Another kind of mini-tablet was compressed from a sodium benzoate compression mixture and finally coated with ethylcellulose. The coating of the tablets was performed using fluidized bed technology. The sodium benzoate release plots of the coated pellets show a lag time and retarded release according first-order kinetics. The mini-tablets and normal tablets compressed from pellets release sodium benzoate according to first-order kinetics as well, but without the lag time due to distinct ethylcellulose layer destruction during tableting. The release is retarded with increasing ethylcellulose layer thickness on directly compressed mini-tablets. The different formulations of coated pellets, mini-tablets, and normal tablets offer a broad choice for variable drug release kinetics depending on the biopharmaceutical and pharmacological requirements.

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Probing fluconazole deposition inside mesoporous silica using solid-state NMR spectroscopy: Crystallization of a confined metastable form and phase transformations under storage conditions

Nowak,

Dyba,

Gołkowska

et al. 2023

International Journal of Pharmaceutics

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Influence of storage condition on properties of MCC II-based pellets with theophylline-monohydrate

Cited by 9 publications

References 13 publications

Silicified microcrystalline cellulose based pellets and their physicochemical properties

Silicified microcrystalline cellulose based pellets and their physicochemical properties

Comparison of Mini-Tablets and Pellets as Multiparticulate Drug Delivery Systems for Controlled Drug Release

Probing fluconazole deposition inside mesoporous silica using solid-state NMR spectroscopy: Crystallization of a confined metastable form and phase transformations under storage conditions

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