Influence of Stress on the Degradation Behavior of Mg LAE442 Implant Systems

Denkena, Berend; Köhler, Jens; Stieghorst, Jan; Turger, Anke; Seitz, Jan‐Marten; Fau, Danielle R.; Wolters, Leonie; Angrisani, Nina; Reifenrath, Janin; Helmecke, Patrick

doi:10.1016/j.procir.2013.01.038

Cited by 20 publications

(7 citation statements)

References 5 publications

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“…This bone formation occurred over the devices, 447where periosteal and muscle tissue layers are typically present,448 suggesting the ability of Mg-ion release from device degradation 449 to affect osteoblastic cell differentiation. This observation is in450 accordance with our previous study in which de novo bone formation was observed around Mg plates and screws after 4 weeks[21], as well as a previous report of LAE442 screws and plates implanted453 in intact rabbit tibia[36]. With the present study, we have confirmed our pilot study observations, and demonstrated that prolonged exposure to Mg degradation can cause progressive bone456 formation.…”

supporting

confidence: 92%

In vivo study of magnesium plate and screw degradation and bone fracture healing

et al. 2015

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supporting

confidence: 92%

In vivo study of magnesium plate and screw degradation and bone fracture healing

et al. 2015

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“…The original HP-Mg staple was designed according to the clinical used U-shape titanium staple. Considering the high stress corrosion sensitivity of magnesium [9] , [10] , [11] , the interior angles of the modified staple were designed to 100°. The closure of the staples were performed through the linear cutter stapler (MLC-60, Nanjing Maidixin Medical Device Co., Ltd. China).…”

Section: Methodsmentioning

confidence: 99%

Research of a novel biodegradable surgical staple made of high purity magnesium

Zhao

et al. 2016

Bioactive Materials

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Surgical staples made of pure titanium and titanium alloys are widely used in gastrointestinal anastomosis. However the Ti staple cannot be absorbed in human body and produce artifacts on computed tomography (CT) and other imaging examination, and cause the risk of incorrect diagnosis. The bioabsorbable staple made from polymers that can degrade in human body environment, is an alternative. In the present study, biodegradable high purity magnesium staples were developed for gastric anastomosis. U-shape staples with two different interior angles, namely original 90° and modified 100°, were designed. Finite element analysis (FEA) showed that the residual stress concentrated on the arc part when the original staple was closed to B-shape, while it concentrated on the feet for the modified staple after closure. The in vitro tests indicated that the arc part of the original staple ruptured firstly after 7 days immersion, whereas the modified one kept intact, demonstrating residual stress greatly affected the corrosion behavior of the HP-Mg staples. The in vivo implantation showed good biocompatibility of the modified Mg staples, without inflammatory reaction 9 weeks post-operation. The Mg staples kept good closure to the Anastomosis, no leaking and bleeding were found, and the staples exhibited no fracture or severe corrosion cracks during the degradation.

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“…Though Mg and its alloys have so many merits, medical transformation is still having a long way to go. The Mg-based bone plates, for example, bone plate and screws made of the LAE442 alloy were shown to severely corrode in the bone plate/screws contact area, which is attributed to the localized corrosion induced by the compressive stress between them [81]. In China, Wu et al [82] observed firstly the crevice corrosion morphology of the screw head without contact with the plate was different from the contact regions in the screw between the screw and the plate on the bone of rat.…”

Section: Discussionmentioning

confidence: 99%

Translational status of biomedical Mg devices in China

Sun

Wang

et al. 2019

Bioactive Materials

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Magnesium (Mg) and its alloys as temporary medical implants with biodegradable and properly mechanical properties have been investigated for a long time. There are already three kinds of biodegradable Mg implants which are approved by Conformite Europeene (CE) or Korea Food and Drug Administration (KFDA), but not China Food and Drug Administration (CFDA, now it is National Medical Products Administration, NMPA). As we know, Chinese researchers, surgeons, and entrepreneurs have tried a lot to research and develop biodegradable Mg implants which might become other new approved implants for clinical applications. So in this review, we present the representative Mg implants of three categories, orthopedic implants, surgical implants, and intervention implants and provide an overview of current achievement in China from academic publications and Chinese patents. We would like to provide a systematic way to translate Mg and its alloy implants from experiment designs to clinical products.

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Influence of Stress on the Degradation Behavior of Mg LAE442 Implant Systems

Cited by 20 publications

References 5 publications

In vivo study of magnesium plate and screw degradation and bone fracture healing

In vivo study of magnesium plate and screw degradation and bone fracture healing

Research of a novel biodegradable surgical staple made of high purity magnesium

Translational status of biomedical Mg devices in China

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