New dental materials are often introduced into the market and especially in the current practice, without a basic understanding of their clinical performance because long-term controlled clinical trials are required, which are both time consuming and expensive. Ceramic materials are known for their relatively high fracture resistance and improved aesthetics, but britleness remains a concern. The stressed areas of the materials are key factors for the failure analysis, and numerical simulations may play an important role in the understanding of the behavior of all-ceramic restorations. Simulation-based medicine and the development of complex computer models of biological structures are becoming ubiquitous for advancing biomedical engineering and clinical research. The studies have to be focused on the analysis of all-ceramic restorations failures, investigating several parameters involved in the tooth structure-restoration complex, in order to improve clinical performances. The experiments have to be conducted and interpreted reported to the britle behavior of ceramic systems. Varied simulation methods are promising to assess the biomechanical behavior of all-ceramic systems, and irst principal stress criterion is an alternative for ceramic materials investigations. The development of well-designed experiments could be useful to help to predict the clinical behavior of these new allceramic restorative techniques and materials.