Influence of Supplementary Vitamin D on Bone Mineral Density When Used in Combination with Selective Estrogen Receptor Modulators

Abstract

Objectives Vitamin D is regarded as one of the major nutrients that significantly influence bone metabolism. This study aims to look at the effect of supplementary vitamin D on bone mineral density (BMD) in female osteoporosis patients. Methods The retrospective hospital record review was performed on 282 patients who were diagnosed with osteoporosis and treated with selective estrogen receptor modulators (SERMs) between January 2015 and December 2016. Of these patients, 151 were treated with SERMs only while 131 were treated using both SERMs and vitamin D supplements. The BMD and any occurrence of osteoporotic fracture episode were investigated after one year. The result of two groups was compared to find the significance of vitamin D. Results Overall, improvement in BMD score was observed in 76% of the patients. The BMD of the SERMs only group improved by 3% in spine and 1% in the hip while that of the SERMs with vitamin D group improved by 6% and 1% respectively. Statistical significance was noticed in the spine only. One distal radius fracture and one single level vertebral fracture occurred in patients of SERMs group while two distal radius fractures occurred in SERMs with vitamin D group. There was no occurrence of around hip fracture in both groups. Conclusion The result of the current study suggests that additional vitamin D may have some additive effect on improving BMD of the spine. Further study with the larger study population and the extended study period is recommended.

The Efficacy of Selective Estrogen Receptor Modulators Monotherapies in Postmenopausal Women with Osteopenia

“…Reid et al [27] insisted that the benefit of using vitamin D to improve BMD is questionable. However, Liu et al [28] suggested that the SERMs with vitamin D may have some additive effect on improving BMD. However, there are a few reports that assess the effect of SERMs with vitamin D. In this study, SERMs with vitamin D tended to have https://doi.org/10.11005/jbm.2022.29.3.185 a larger increase of BMD than SERMs monotherapies.…”

A randomized controlled trial of the effect of raloxifene plus cholecalciferol versus cholecalciferol alone on bone mineral density in postmenopausal women with osteopenia

“…Raloxifene has been shown to increase lumbar spine BMD and reduce fracture risk in patients with osteoporosis, with a recent study demonstrating additional BMD improvement when it is given in combination with cholecalciferol. 11 , 12 Furthermore, the drug may be more widely prescribed in clinical practice given its superior safety profile when compared with bisphosphonates, particularly in the context of medication-related osteonecrosis of the jaw and atypical femoral fracture. 13 , 14 Raloxifene has an advantage over combined estrogen and progestin therapy in reducing the risk of breast cancer.…”