Influence of surface charge of graphene quantum dots on their uptake and clearance in melanoma cells

Ramana, Lakshmi Narashimhan; Đình, Lê; Agarwal, Vipul

doi:10.1039/d0na00935k

Cited by 19 publications

(19 citation statements)

References 54 publications

(71 reference statements)

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“…The Raman spectra of GQDs and MA‐GQDs are shown in Figure 9. The GQD spectrum reveals the presence of the characteristic D and G bands at 1365 cm −1 and 1597 cm −1 respectively, comparable to what has been previously reported, [ 30 ] while the spectrum of MA‐GQDs shows the D and G bands at 1428 cm −1 and 1597 cm −1 respectively. The Raman spectrum of MA‐GQDs indicated a red‐shift of the D band and decrease in intensity of G band, which may be a result of the changes in the surface chemistry of the materials affecting the interaction of the photons.…”

Section: Resultssupporting

confidence: 88%

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Development of a mycolic acid‐graphene quantum dot probe as a potential tuberculosis biosensor

et al. 2022

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The development of amine‐functionalized graphene quantum dots (GQDs) linked to mycolic acids (MAs) as a potential fluorescent biosensor to detect tuberculosis (TB) biomarkers is described. GQDs have attractive properties: high fluorescence, excellent biocompatibility, good water solubility, and low toxicity. MAs are lipids that are found in the cell wall of Mycobacterium tuberculosis that are antigenic, however, they are soluble only in chloroform and hexane. Chloroform‐soluble MAs were covalently linked to synthesized water‐soluble GQDs using an amide connection to create a potential fluorescent water‐soluble TB biosensor: MA‐GQDs. Fluorescence results showed that GQDs had a narrow emission spectrum with the highest emission at 440 nm, while MA‐GQDs had a broader spectrum with the highest emission at 470 nm, after exciting at 360 nm. The appearance of the peptide bond (amide linkage) in the Fourier‐transform infrared spectrum of MA‐GQDs confirmed the successful linking of MAs to GQDs. Powder X‐ray diffraction exhibited an increase in the number of peaks for MA‐GQDs relative to GQDs, suggesting that linking MAs to GQDs changed the crystal structure thereof. The linked MA‐GQDs showed good solubility in water, high fluorescence, and visual flow through a nitrocellulose membrane. These properties are promising for biomedical fluorescence sensing applications.

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Section: Resultssupporting

confidence: 88%

“…The GQD spectrum reveals the presence of the characteristic D and G bands at 1365 cm À1 and 1597 cm À1 respectively, comparable to what has been previously reported, [30] while the spectrum of MA-GQDs…”

Section: Raman Spectra Of Gqds and Ma-gqdssupporting

confidence: 87%

Development of a mycolic acid‐graphene quantum dot probe as a potential tuberculosis biosensor

et al. 2022

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“…FTIR and Raman spectroscopy were conducted to further characterize the nanocomposite films. FTIR analysis of neat LS revealed characteristic peaks at 3375, 1568, 1410, 1000–1100, and 618 cm –1 corresponding to an −OH stretching peak from phenolic and carboxylic acids, −CC– stretching, −SO stretching, −C–O stretching band from primary, secondary alcohols and aliphatic ether of LS, and −C–H vibration, respectively (Figure f). , In the case of the P( n BA- stat -BzMA)/rGO film, characteristic peaks for the −CO stretching band, −C–H bending band from the methyl group, −C–O stretching vibration, and a strong −C–H band originating from a substituted benzene derivative (BzMA) were observed at 1724, 1455, 1000–1100, and 680–760 cm –1 , respectively (Figure f). − We observed the presence of peaks from both P( n BA- stat -BzMA)/rGO and LS in the P( n BA- stat -BzMA)/rGO/LS films as expected. For example, the presence of peaks, such as 1728, 1455, and ∼700–760 cm –1 , was a contribution from P( n BA- stat -BzMA)/rGO, whereas peaks at 3375, 1571, 1396, 1000–1100, and 617 cm –1 can be assigned to the contribution from LS (Figure f).…”

Section: Resultsmentioning

confidence: 99%

“…FTIR analysis of neat LS revealed characteristic peaks at 3375, 1568, 1410, 1000−1100, and 618 cm −1 corresponding to an −OH stretching peak from phenolic and carboxylic acids, −CC− stretching, −SO stretching, −C−O stretching band from primary, secondary alcohols and aliphatic ether of LS, and −C−H vibration, respectively (Figure 3f). 40,41 In the case of the P(nBA-stat-BzMA)/rGO film, characteristic peaks for the −CO stretching band, −C−H bending band from the methyl group, −C−O stretching vibration, and a strong −C−H band originating from a substituted benzene derivative (BzMA) were observed at 1724, 1455, 1000−1100, and 680− 760 cm −1 , respectively (Figure 3f). 42−44 We observed the presence of peaks from both P(nBA-stat-BzMA)/rGO and LS in the P(nBA-stat-BzMA)/rGO/LS films as expected.…”

Section: Resultsmentioning

confidence: 99%

Polymer/Reduced Graphene Oxide/Lignosulfonate Nanocomposite Films as Pseudocapacitor Cathodes

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et al. 2022

ACS Appl. Nano Mater.

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Robust and electrochemically stable electrodes are critical for emerging energy storage devices. In this work, we describe the synthesis and characterization of an asymmetric pseudocapacitor with a P(nBA-stat-BzMA)/reduced graphene oxide (rGO, 5 wt %) nanocomposite cathode incorporating a low content of lignosulfonate (LS, 5 wt %) and a P(nBA-stat-BzMA)/rGO anode. Besides the advantageous green source and low cost of LS, its properties as a binder and its redox groups contribute to the electrochemical performance improvement of the pseudocapacitor. First, the electrochemical optimization and characterization of an asymmetric unit cell is performed. Subsequently, a series of 10 unit cells are arranged in a "stack of cells"; electrochemical tests show this assembly to have a capacitance of 4.90 F cm −3 (8.60 F g −1 ), maximum power of 610 W kg −1 , energy of 4.32 W h kg −1 , loss of electroactivity of 1.8%, capacitance retention of 98%, and Coulombic efficiency of 108% after 1000 charge−discharge cycles at a constant current of 0.12 A cm −3 . Morphological analysis revealed an increase in surface roughness after LS incorporation within the cathode. Electrode−electrolyte resistances were calculated via electrochemical impedance spectroscopy, which allowed us to propose a model of electrode−electrolyte interaction for this system.

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“…Optical [138], electrical [139], and biological [140,141] properties of GQDs are intrinsically dependent on their size. For instance, Deng and coauthors demonstrated the influence of size over the electrocatalytic activity of graphene exfoliated via ball milling.…”

Section: Effect Of the Size Of Gqds In Their Electrochemical Performancementioning

confidence: 99%

Graphene Quantum Dots-Based Nanocomposites Applied in Electrochemical Sensors: A Recent Survey

et al. 2021

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Graphene quantum dots (GQDs) have been widely investigated in recent years due to their outstanding physicochemical properties. Their remarkable characteristics allied to their capability of being easily synthesized and combined with other materials have allowed their use as electrochemical sensing platforms. In this work, we survey recent applications of GQDs-based nanocomposites in electrochemical sensors and biosensors. Firstly, the main characteristics and synthesis methods of GQDs are addressed. Next, the strategies generally used to obtain the GQDs nanocomposites are discussed. Emphasis is given on the applications of GQDs combined with distinct 0D, 1D, 2D nanomaterials, metal-organic frameworks (MOFs), molecularly imprinted polymers (MIPs), ionic liquids, as well as other types of materials, in varied electrochemical sensors and biosensors for detecting analytes of environmental, medical, and agricultural interest. We also discuss the current trends and challenges towards real applications of GQDs in electrochemical sensors.

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Influence of surface charge of graphene quantum dots on their uptake and clearance in melanoma cells

Abstract: Graphene quantum dots (GQDs) continue to draw interest in biomedical applications. However, their efficacy gets compromised due to their rapid clearance from body. On one side, rapid clearance is desired...

Cited by 19 publications

References 54 publications

Development of a mycolic acid‐graphene quantum dot probe as a potential tuberculosis biosensor

Development of a mycolic acid‐graphene quantum dot probe as a potential tuberculosis biosensor

Polymer/Reduced Graphene Oxide/Lignosulfonate Nanocomposite Films as Pseudocapacitor Cathodes

Graphene Quantum Dots-Based Nanocomposites Applied in Electrochemical Sensors: A Recent Survey

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