Influence of surface electric charge of Ti implants on osteoblastic interaction: A systematic review

Tardelli, Juliana Dias Corpa; Reis, Andréa Cândido dos

doi:10.1016/j.sdentj.2022.04.003

Cited by 11 publications

(4 citation statements)

References 69 publications

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“…The zeta potential values of the Zn-free and Zn-containing PEO coatings are approximately the same and amount to −13 and −12 mV, respectively. The negatively charged implant surface attracts positively charged Ca 2+ ions from the biological environment, which are deposited on the surface and act as a driving force for biomineralization, causing osteoblastic attraction and differentiation …”

Section: Resultsmentioning

confidence: 99%

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Synergistic Bactericidal Effect of Zn²⁺ Ions and Reactive Oxygen Species Generated in Response to Either UV or X-ray Irradiation of Zn-Doped Plasma Electrolytic Oxidation TiO₂ Coatings

Popova,

Advakhova,

Sheveyko

et al. 2024

ACS Appl. Bio Mater.

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Zn-containing TiO 2 -based coatings with Na, Ca, Si, and K additives were obtained by plasma electrolytic oxidation (PEO) of Ti in order to achieve an effective and broad bactericidal protection without compromising biocompatibility. A protocol has been developed for cleaning the coating surface from electrolyte residues, ensuring the preservation of the microstructure and composition of the surface layer. Using high-resolution transmission electron microscopy, three characteristic microstructural zones in the PEO-Zn coating are well documented: zone 1 with a TiO 2 -based nanocrystalline structure, zone 2 with an amorphous structure, and zone 3 around pores with an amorphous-nanocrystalline structure. The excellent cytocompatibility of PEO-Zn samples was confirmed by three different methods: monitoring the proliferation of MC3T3-E1 cells, assessing the viability of sheep osteoblast cells using calcein-AM staining and fluorescence microscopy, and incubation with spheroids based on primary osteoblast cells and mouse embryonic fibroblast NIH3T3 cells. The PEO-Zn coatings absorb >60% of the incident light over the UV and Vis-NIR spectral ranges. After 24 h, the PEO-Zn coatings completely inactivate four types of strains: Gram-positive Staphylococcus aureus CSA154 and ATCC29213 and Gram-negative Escherichia coli K261 and U20, and also prevent E. coli U20 and K261 biofilm formation. The superior antibacterial activity is associated with the synergistic effect of Zn 2+ ions in safe concentration and reactive oxygen species (ROS) generated in response to either UV irradiation or soft short-term X-ray irradiation. The X-ray irradiationinduced ROS formation by a PEO coating is reported for the first time. The enhanced bactericidal activity after X-ray irradiation compared to UV illumination is attributed to the more intense ROS generation in the first few hours. The results obtained significantly expand the possibilities of using PEO coatings on the surfaces of titanium implants.

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Section: Resultsmentioning

confidence: 99%

“…The negatively charged implant surface attracts positively charged Ca 2+ ions from the biological environment, which are deposited on the surface and act as a driving force for biomineralization, causing osteoblastic attraction and differentiation. 43 3.5. Zn Ion Release.…”

Section: Wettability and Zeta Potential Of Peo Coatingsmentioning

confidence: 99%

Synergistic Bactericidal Effect of Zn²⁺ Ions and Reactive Oxygen Species Generated in Response to Either UV or X-ray Irradiation of Zn-Doped Plasma Electrolytic Oxidation TiO₂ Coatings

Popova,

Advakhova,

Sheveyko

et al. 2024

ACS Appl. Bio Mater.

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“…As the difference in roughness caused by the different additive manufacturing methods evaluated is an important parameter to be considered, the authors of this review can infer that all the values found were biocompatible for osteoblastic adhesion and proliferation and it is not possible to determine the best roughness and technique due to the heterogeneity of the studies. However, as the increase in this favors the increase in the available surface area in vivo, it may favor the mechanical imbrication [ 34 , 35 , 55 , 56 , 57 , 58 ], while, in cellular terms, this should be correlated with the morphology of the peaks and valleys as well as the hydrophilicity and electrostatic condition of the surface that interact synergistically for osseointegration [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of the roughness of dental implants obtained by additive manufacturing on osteoblastic adhesion and proliferation: A systematic review

Tardelli¹,

Firmino²,

Ferreira³

et al. 2022

Heliyon

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“…Albumin adsorption decreased with a decrease in surface free energy, leading to a decrease in α-helix content . Complementary studies have also evaluated the effect of surface free energy components (dispersive and polar) on fibronectin and albumin adsorption, observing an increase in concentration of these proteins on surfaces that have a higher polar component. ,− In terms of crystallography, Struczyńska et al. observed that the orientation and surface energy of single rutile crystals affect fibronectin conformation .…”

Section: The Role Of Surface Properties On Protein Adsorption (Fbr Ph...mentioning

confidence: 99%

Osteointegration of Ti Bone Implants: A Study on How Surface Parameters Control the Foreign Body Response

Mesa-Restrepo,

Byers,

Brown

et al. 2024

ACS Biomater. Sci. Eng.

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The integration of titanium (Ti)-based implants with bone is limited, resulting in implant failure. This lack of osteointegration is due to the foreign body response (FBR) that occurs after the implantation of biodevices. The process begins with protein adsorption, which is governed by implant surface properties, e.g., chemistry, charge, wettability, and/or topography. The distribution and composition of the protein layer in turn influence the recruitment, differentiation, and modulation of immune and bone cells. The subsequent events that occur at the bone−material interface will ultimately determine whether the implant is encapsulated or will integrate with bone. Despite the numerous studies evaluating the influence of surface properties in the various stages of the FBR, the factors that affect tissue− material interactions are often studied in isolation or in small correlations due to the technical challenges involved in assessing them in vitro or in vivo. Consequently, the influence of protein conformation on the Ti bone implant surface design remains an unresolved research question. The objective of this review is to comprehensively evaluate the existing literature on the effect of surface parameters of Ti and its alloys in the stages of FBR, with a particular focus on protein adsorption and osteoimmunomodulation. This evaluation aims to systematically describe these effects on bone formation.

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Influence of surface electric charge of Ti implants on osteoblastic interaction: A systematic review

Cited by 11 publications

References 69 publications

Synergistic Bactericidal Effect of Zn²⁺ Ions and Reactive Oxygen Species Generated in Response to Either UV or X-ray Irradiation of Zn-Doped Plasma Electrolytic Oxidation TiO₂ Coatings

Synergistic Bactericidal Effect of Zn²⁺ Ions and Reactive Oxygen Species Generated in Response to Either UV or X-ray Irradiation of Zn-Doped Plasma Electrolytic Oxidation TiO₂ Coatings

Influence of the roughness of dental implants obtained by additive manufacturing on osteoblastic adhesion and proliferation: A systematic review

Osteointegration of Ti Bone Implants: A Study on How Surface Parameters Control the Foreign Body Response

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Influence of surface electric charge of Ti implants on osteoblastic interaction: A systematic review

Cited by 11 publications

References 69 publications

Synergistic Bactericidal Effect of Zn2+ Ions and Reactive Oxygen Species Generated in Response to Either UV or X-ray Irradiation of Zn-Doped Plasma Electrolytic Oxidation TiO2 Coatings

Synergistic Bactericidal Effect of Zn2+ Ions and Reactive Oxygen Species Generated in Response to Either UV or X-ray Irradiation of Zn-Doped Plasma Electrolytic Oxidation TiO2 Coatings

Influence of the roughness of dental implants obtained by additive manufacturing on osteoblastic adhesion and proliferation: A systematic review

Osteointegration of Ti Bone Implants: A Study on How Surface Parameters Control the Foreign Body Response

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Product

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Synergistic Bactericidal Effect of Zn²⁺ Ions and Reactive Oxygen Species Generated in Response to Either UV or X-ray Irradiation of Zn-Doped Plasma Electrolytic Oxidation TiO₂ Coatings

Synergistic Bactericidal Effect of Zn²⁺ Ions and Reactive Oxygen Species Generated in Response to Either UV or X-ray Irradiation of Zn-Doped Plasma Electrolytic Oxidation TiO₂ Coatings